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Safety and Tolerability of ABM-1310 in Patients With Advanced Solid Tumors

ABSTRACT: This is a Phase I, First-In-Human, open label, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-cancer activity of ABM-1310 in adult patients with locally advanced or metastatic solid tumors who have no effective standard treatment options available, as monotherapy in patients with documented BRAF V600 mutation, or in combination with cobimetinib (Cotellic) in adult patients who have documented BRAF mutation and progressive disease or intolerance to at least one prior line of systemic therapy.

DISEASE(S): Ovarian Cancer,Thyroid Cancer,Glioblastoma,Melanoma,Colorectal Cancer,Non-small Cell Lung Cancer,Advanced Solid Tumor,Braf V600 Mutation,Neoplasms

PROVIDER: 2324043 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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DETERMINE Trial Treatment Arm 05: Vemurafenib in Combination With Cobimetinib in Adult Patients With BRAF Positive Cancers.

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A Phase I Study of Oral LGX818 in Adult Patients With Advanced or Metastatic BRAF Mutant Melanoma

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Gene expression of the A375 melanoma cell line treated with RAF inhibitors Vemurafenib and time-course with EGF stimulation during Vemurafenib RAF inhibitor treatment alone or with the MEK inhibitor Cobimetinib

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