PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

ABSTRACT: This phase I trial studies the side effects of pressurized intraperitoneal aerosol chemotherapy (PIPAC) in treating patients with ovarian, uterine, appendiceal, stomach (gastric), or colorectal cancer that has spread to the lining of the abdominal cavity (peritoneal carcinomatosis). Chemotherapy drugs, such as cisplatin, doxorubicin, oxaliplatin, leucovorin, fluorouracil, mitomycin, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. PIPAC is a minimally invasive procedure that involves the administration of intraperitoneal chemotherapy. The study device consists of a nebulizer (a device that turns liquids into a fine mist), which is connected to a high-pressure injector, and inserted into the abdomen (part of the body that contains the digestive organs) during a laparoscopic procedure (a surgery using small incisions to introduce air and to insert a camera and other instruments in the abdominal cavity for diagnosis and/or to perform routine surgical procedures). Pressurization of the liquid chemotherapy through the study device results in aerosolization (a fine mist or spray) of the chemotherapy intra-abdominally (into the abdomen). Giving chemotherapy through PIPAC may reduce the amount of chemotherapy needed to achieve acceptable drug concentration, and therefore potentially reduces side effects and toxicities.

DISEASE(S): Stage Iva Colorectal Cancer Ajcc V8,Stage Iva Uterine Corpus Cancer Ajcc V8,Postneoadjuvant Therapy Stage Iv Gastric Cancer Ajcc V8,Clinical Stage Ivb Gastric Cancer Ajcc V8,Malignant Uterine Neoplasm,Metastatic Malignant Solid Neoplasm,Carcinoma,Metastatic Appendix Carcinoma,Stage Ivc Appendix Carcinoma Ajcc V8,Stage Iv Appendix Carcinoma Ajcc V8,Metastatic Colorectal Carcinoma,Peritoneal Carcinomatosis,Neoplasms,Appendiceal Neoplasms,Stage Ivb Colorectal Cancer Ajcc V8,Stage Iv Ovarian Cancer Ajcc V8,Stage Ivb Ovarian Cancer Ajcc V8,Metastatic Malignant Neoplasm In The Peritoneum,Colorectal Neoplasms,Ovarian Neoplasms,Stomach Neoplasms,Clinical Stage Iva Gastric Cancer Ajcc V8,Clinical Stage Iv Gastric Cancer Ajcc V8,Stage Iv Uterine Corpus Cancer Ajcc V8,Stage Ivc Colorectal Cancer Ajcc V8,Stage Iv Colorectal Cancer Ajcc V8,Metastatic Ovarian Carcinoma,Stage Ivb Uterine Corpus Cancer Ajcc V8,Stage Iva Appendix Carcinoma Ajcc V8,Metastatic Gastric Carcinoma,Pathologic Stage Iv Gastric Cancer Ajcc V8,Peritoneal Neoplasms,Uterine Neoplasms,Stage Iva Ovarian Cancer Ajcc V8,Carcinoma, Ovarian Epithelial,Stage Ivb Appendix Carcinoma Ajcc V8

PROVIDER: 2334713 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR