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Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

ABSTRACT: This is a phase Ib/II open label study. The escalation part will characterize the safety and tolerability of JDQ443 single agent and JDQ443 in combination with the other study treatments (TNO155 and tislelizumab) in advanced solid tumor patients. After the determination of the maximum tolerated dose / recommended dose for a particular treatment arm, dose expansion will assess the anti-tumor activity and further assess the safety, tolerability, and PK/PD of each regimen at the maximum tolerated dose / recommended dose or lower dose.

DISEASE(S): Non-small-cell Lung, Carcinoma,Colorectal,Lung Cancer,Carcinoma,Kras G12c Mutant Solid Tumors,Pulmonary Neoplasms,Colorectal Cancer,Advanced Cancer,Cancer Of The Lung,Advanced Solid Tumors Harboring The Kras G12c Mutation,Lung Neoplasms,Neoplasms,Carcinoma, Colorectal,Kras G12c Mutant Solid Tumors, Carcinoma,Kras G12c,Pulmonary Cancer,Colorectal Neoplasms,Neoplasms, Pulmonary,Cancer Of Lung,Carcinoma, Non-small-cell Lung,Neoplasms, Lung

PROVIDER: 2363112 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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