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Effect of Jianpi Huatan Decoction on Advanced Colorectal Cancer

ABSTRACT: This study will take progression-free survival and overall survival as the main evaluation indexes, to evaluate the Efficacy of Jianpi Huatan Decoction in the Treatment of Advanced Colorectal Cancer. Decision Trees and Discriminant Analysis will be used to analyze the characteristics of dominant population combined with clinical data of patients. DNA methylation of the subjects will be detected to study the methylation characteristics of the preponderant population of Jianpi Huatan Decoction.

DISEASE(S): Colorectal Cancer,Colorectal Neoplasms

PROVIDER: 2400655 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Efficacy and safety of Jianpi Bushen Decoction on the chemotherapy induced myelosuppression in patients with colorectal cancer: a randomized controlled trial

Project description:Interventions: TCM and chemotherapy:Jianpi Bushen Decoction combined with chemotherapy;Chemotherapy:Chemotherapy Primary outcome(s): Peripheral blood leukocytes Study Design: Randomized parallel controlled trial

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Plant microRNA profiling of Honeysuckle and Honeysuckle Decoction

Project description:Influenza A viruses (IAVs), particularly H1N1, H5N1 and H7N9, pose a substantial threat to public health worldwide. Here, we report that MIR2911, a honeysuckle (HS)-encoded atypical microRNA, directly targets IAVs with a broad spectrum. MIR2911 is highly stable in HS decoction, and continuous drinking or gavage feeding of HS decoction leads to a significant elevation of the MIR2911 level in mouse peripheral blood and lung. Bioinformatics prediction and a luciferase reporter assay showed that MIR2911 could target various IAVs, including H1N1, H5N1 and H7N9. Synthetic MIR2911 significantly inhibited H1N1-encoded PB2 and NS1 protein expression but did not affect mutants in which the MIR2911-binding nucleotide sequences were altered. Synthetic MIR2911, extracted RNA from HS decoction and HS decoction all significantly inhibited H1N1 viral replication and improved viral infection-induced mouse weight loss but did not affect infection with a mutant virus in which the MIR2911-binding nucleotide sequences of PB2 and NS1 were altered. Importantly, the inhibitory effect of HS decoction on viral replication was abolished by an anti-MIR2911 antagomir, indicating that the physiological concentration of MIR2911 in HS decoction could directly and sufficiently suppress H1N1 viral replication. MIR2911 also inhibited H5N1 and H7N9 viral replication in vitro and in vivo. Strikingly, administration of MIR2911 or HS decoction both dramatically reduced mouse mortality caused by H5N1 infection. Our results demonstrate that MIR2911 is the first active component identified in Traditional Chinese Medicine to directly target various IAVs and may represent a novel type of natural product that effectively suppresses viral infection. Screening and profiling of known plant microRNA in HS and HS decoction

2014-10-22 | E-GEOD-55268 | biostudies-arrayexpress

Gene expression biomarkers discovery for the Sini Decoction Pattern

Project description:We aimed to investigate the syndrome of Sini decoction pattern. The Sini decoction was first mentioned in Shang Han Za Bing Lun, then was developed into Sini decoction pattern (SDP) by Sun Simiao’s Qian Jin Yi Fang. The syndromes of SDP were correlated with various extremely Yang deficiency related symptoms, but there does not exist common definition.

2015-03-20 | GSE67090 | GEO

Plant microRNA profiling of Honeysuckle and Honeysuckle Decoction

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The analysis of gene transcription and the effect of drug resistance of Radix Paeoniae Rubra Decoction on Staphylococcus aureus

Project description:To study the effect of Radix Paeoniae Rubra decoction on tolerance of Staphylococcus aureus.The effect of Radix Paeoniae Rubra on the resistance of Staphylococcus aureus to oxacillin sodium was studied by millipore dilution method in this experiment.At the same time ,conducted on transcriptome analysis of Staphylococcus aureus related genes in Radix Paeoniae Rubra.And to detect the expression level of related genes of Staphylococcus aureus under the action of Radix Paeoniae Rubra by PCR technology.The tolerance of Staphylococcus aureus was decreased obviously when the concentration of Radix Paeoniae Rubra decoction was above 1mg/ml.The effect of Radix Paeoniae Rubra decoction on the expression of tolerance genes femB,pvL and gluM when the concentration of Radix Paeoniae Rubra decoction was above 4mg/ml.When rhe concentration of Radix Paeoniae Rubra is more than 1mg/ml,it can effectively reduce the resistance of Staphylococcus aureus to oxacillin sodium.The reason may be due to the effect of Radix Paeoniae Rubra on the resistance gene of Staphylococcus aureus.

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Mouse CSF Analyses of middle cerebral ischemic/reperfusion (CI/R) injury followed by Buyang Huanwu Decoction

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2019-02-16 | PXD006342 | Pride

Quantitative Proteomics Revealed the Changes of Pharmacodynamic Network of Bugu Shengsui Decoction Promoting Osteoblasts Proliferation

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2022-01-28 | PXD030275 | Pride

Effects of Buyang Huanwu Decoction on circRNA-miRNA-mRNA transcriptional network of rats with cerebral ischemia

Project description:To reveal the effects of Buyang Huanwu Decoction on circRNA-miRNA-mRNA transcriptional network of rats with cerebral ischemia, explore its molecular mechanism for the treatment of cerebral ischemia.

2022-01-04 | GSE178439 | GEO

Effects of Huatan Jiangzhuo Decoction and Poria cocos - Alismatis Rhizoma on gene expression in liver of rats with hyprelipidemia

Project description:Huatan Jiangzhuo Decoction, a traditional Chinese medicine composition, has been used to treat patients with hyperlipidemia (HLP). To investigate the therapeutic mechanism of Huatan Jiangzhuo decoction(HTJZD) and Poria cocos (PC) - Alismatis Rhizoma (AR) on gene expression in liver of rats with HLP, this study performed gene expression profiling analysis using data obtained from RNA-seq technology. It’s predicted that the potential role of regulating the expression of differentially expressed genes in the treatment of HLP by HTJZD and PC-AR separately.

2023-06-30 | GSE212771 | GEO

Identification of candidate targets for Haizao Yuhu Decoction acting on goiter rats

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