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Effects of supervised physical activity on endurance capacity in colorectal cancer patients undergoing ambulatory Chemotherapy

ABSTRACT: Interventions: Group 1: With beginning of the chemotherapy a standardized endurance training of 15/30 min will be accomplished within 24 weeks. 2 sessions per week will be passed on a bicycle ergometer (30min) and 3 sessions will be passed by a walking or Nordic walking program (15min). The first 10 sessions are supervised to ensure controlled environment. From week 3 patients exercise only the 2 sessions on bicycle ergometer under supervision. At the beginning the intensity is defined as 50% of the maximum endurance capacity and increases during the next 10 sessions on 70%. The exercise program accords to an intensive endurance training. Group 2: patients receive general recommendations for regular physical activity, including 3 times subjectively moderate endurance training per week. primary outcome is the physical fitness, measured by spiroergometry before and after intervention (24 weeks after baseline), and at the 3 year follow-up. Study Design: Allocation: Randomized controlled study; Masking: Open (masking not used); Control: active; Assignment: parallel; Study design purpose: supportive care

DISEASE(S): Malignant Neoplasm Of Colon

PROVIDER: 2430473 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Project description:Context: Exercise training is a plausible model for identification of molecular mechanisms that cause metabolic-related changes in human skeletal muscle. Objective: The goal was to explore the molecular basis of the adaptation of skeletal muscle to exercise training. Design and Intervention: Obese male subjects were subjected to an individualized supervised training program targeted in order to optimize lipid oxidation during 8 weeks. Main Outcome Measures: Primary outcome measures were gene expression profiling of skeletal muscle. Body composition, oral glucose tolerance test, Resting metabolic rate, respiratory quotient, maximal oxygen uptake and metabolic biochemistry were also assessed. Overall Design The obese (BMI 30-36) male volunteers (age 32-42) were asked to refrain from vigorous physical activity 48h before presenting to the clinical investigation centre, and ate a weight-maintaining diet consisting of 35% fat, 16% protein, and 49% carbohydrates two days before the experiment. Muscle biopsies of Vastus Lateralis weighing 60–100 mg were obtained using the Bergstrom technique, cleaned and snap-frozen in liquid nitrogen. Resting metabolic rate, respiratory quotient and maximal oxygen uptake were assessed. The subjects were investigated at baseline and after 8 weeks of supervised aerobic exercise training program consisting of daily sessions of 45-60 min of endurance exercise, 5 days a week, at least 48-72h after the last acute exercise bout. Skeletal muscle biopsies were obtained at the beginning and at the end of the protocol. Transcriptome analysis compared 8 subjects before vs. after training using arrays using a common reference design (Cy5 dye was incorporated into all muscle RNA samples, while a reference RNA pool made of the mix of commercial human liver, adipose tissue and skeletal muscle RNA was labelled with Cy3 dye (Applied Biosystems/Ambion, Foster City, USA)( and whole genome 4x44k oligonucleotide arrays (Agilent Technologies).

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Effects of supervised physical activity on endurance capacity in colorectal cancer patients undergoing ambulatory Chemotherapy

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