Proteomics

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Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength training


ABSTRACT: Proteomic characterization of skeletal muscle biopsies collected from the vastus lateralis of 44 male and female human subjects. Research subjects were divided in three different groups based on their individual exercise backgrounds and physical performance testing: 1) endurance trained (males; ME, n = 9 and females; FE, n = 9, with at least 15 years’ of regular training experience), 2) strength-trained males (MS, n = 9, with at least 15 years’ of regular training experience), and 3) age-matched healthy untrained controls (males, MC, n = 9 and females FC, n = 8, with a self-reported history of <2 exercise bouts per week over the past 15 years).

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skeletal Muscle, Skeletal Muscle Tissue

SUBMITTER: Georgios Mermelekas  

LAB HEAD: Janne Lehtiö

PROVIDER: PXD044445 | Pride | 2024-01-26

REPOSITORIES: Pride

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Publications

Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength training.

Emanuelsson Eric B EB   Arif Muhammad M   Reitzner Stefan M SM   Perez Sean S   Lindholm Maléne E ME   Mardinoglu Adil A   Daub Carsten C   Sundberg Carl Johan CJ   Chapman Mark A MA  

iScience 20231205 1


Exercise training has tremendous systemic tissue-specific health benefits, but the molecular adaptations to long-term exercise training are not completely understood. We investigated the skeletal muscle proteome of highly endurance-trained, strength-trained, and untrained individuals and performed exercise- and sex-specific analyses. Of the 6,000+ proteins identified, >650 were differentially expressed in endurance-trained individuals compared with controls. Strikingly, 92% of the shared protein  ...[more]

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