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A Phase 1 Study of PT217 in Patients With Advanced Refractory Cancers Expressing DLL3

ABSTRACT: PT217 is a bispecific antibody (bsAb) against human DLL3 (huDLL3) and human CD47 (huCD47). This is an open label, Phase I study to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary efficacy of PT217 in subjects with advanced or refractory cancers. Patients with the following tumor types will be eligible for screening: unresectable or small cell lung cancer (SCLC), large cell neuroendocrine cancer (LCNEC), neuroendocrine prostate cancer (NEPC) and gastroenteropancreatic neuroendocrine tumors (GEP-NET). Subjects must have progressed after standard therapy (platinum-based chemotherapy) or standard therapy has proven to be ineffective, intolerable or was considered inappropriate.

DISEASE(S): Gastroenteropancreatic Neuroendocrine Tumors (gep-net),Neuroendocrine Tumors,Lung Cancer,Small Cell Lung Cancer,Small Cell Lung Carcinoma,Lung Neoplasms,Small Cell Lung Cancer (sclc),Prostatic Neoplasms,Carcinoma, Neuroendocrine,Large Cell Neuroendocrine Cancer (lcnec),Pancreatic Neoplasms,Stomach Neoplasms,Intestinal Neoplasms,Neuroendocrine Prostate Cancer (nepc)

PROVIDER: 2543 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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