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Cancer peptide vaccine therapy for patients with advanced metastatic colorectal cancer. Phase I/II clinical trial.

ABSTRACT: Interventions: Subcutaneous injection of cancer peptide vaccines (five peptides) Primary outcome(s): Safety Responsiveness (tumor size) Study Design: Single arm Non-randomized

DISEASE(S): Colorectal Cancer

PROVIDER: 2620388 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Cancer specific vaccine therapy using HLA-A24 restricted epitope-peptide for patients with advanced metastatic colorectal cancer.PhaseI/II clinical trial.

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Cancer vaccine therapy with HLA-A24 restricted epitope peptide cocktail for patients with advanced metastatic colorectal cancer. Phase I/II clinical trial.

Project description:Interventions: Subcutaneous injection of cancer vaccine (seven peptides) Primary outcome(s): Safty Immunological response (in vitro CTL induction) Study Design: Single arm Non-randomized

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Cancer vaccine therapy with HLA-A24 restricted epitope peptide cocktail for patients with advanced metastatic colorectal cancer. Phase I/II clinical trial.

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A phase II clinical study of cancer vaccine with Survivin helper peptide for patients with advanced/recurrent colorectal cancers

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Personalized neoantigen peptide vaccine for advanced solid cancer

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Phase I/II clinical trial of HLA-A24 restricted epitope peptide cocktail therapy with UFT+LV for patients with advanced metastatic colorectal cancer.

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ClariomS Array to determine the effect of a vaspin-derived peptide on gene expression in fully differentiated primary subcutaneous mouse adipocytes

Project description:Screening for potential target proteases of vaspin revealed rapid and specific cleavage within the vaspin N-terminus, releasing short peptides with cell penetrating activity. For microarray analysis to determine the effect of a vaspin-derived peptide on gene expression in adipocytes, fully differentiated primary mouse adipocytes from subcutaneous AT were treated with 100 nM of peptide for 24 h before harvesting, RNA isolation and microarray analysis. Solvent (water) treated cells served as controls.

2021-03-31 | E-MTAB-9592 | biostudies-arrayexpress

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In situ synthesis of peptide microarrays - shadow mask design [3]

Project description:In this paper several computer programs were used to simulate in situ synthesis of peptides using shadow masks and BOC synthesis. The peptides were designed to be random, or pseudo-random, but fulfill requirements of immunosignaturing. This file contains data from actual 330,000 peptide arrays that used the first iteration of the peptide generation algorithm. Monoclonal antibodies were bound to the microarrays and the total number of peptides that distinguished each monoclonal was measured. This provides a baseline against which to compare purely random sequences. One replicate of each peptide was printed on 1 330k peptide microarray. One microarray were tested for each sample. Image was qualified using in-house metrics for quality assurance.

2014-01-16 | E-GEOD-50571 | biostudies-arrayexpress

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| 2166328 | ecrin-mdr-crc

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