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Research for intraoperative navigation by ICG fluorescence imaging in laparoscopic liver resection

ABSTRACT: Interventions: intravenous administration of ICG Primary outcome(s): Success rate of the visualization of liver tumor by ICG fluorescence imaging. Study Design: Single arm Non-randomized

DISEASE(S): Hepatocellular Carcinoma, Colorectal Liver Metastasis, Liver Tumor

PROVIDER: 2639377 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Indocyanine green (ICG) application to intraoperative navigation of fluorescence imaging

Project description:Interventions: Indocyanine green (ICG) Primary outcome(s): Adverse event Study Design: Single arm Non-randomized

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Intraoperative identification of colonic tumor site using near infrared indocyanine green-induced endosopic fluorescence imaging system

Project description:Interventions: 0.5 ml ICG was injected the mucosa into the submucosal space of the bowel wall at just the distal side of the tumor preoperative endoscopically. We identified the colonic tumor site in the PINPOINT Endoscopic Fluorescence Imaging System, in which NIR fluorescence is superimposed in pseudo-color (green) on a white light image. Primary outcome(s): The intraoperative visibility rate of tumor site Study Design: Single arm Non-randomized

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Regulation of gene expression in uveal melanoma cells by ICG-001

Project description:We examined the effects of ICG-001 on gene expression in Mel202 uveal melanoma (UM) cells. ICG-001 exerted strong antiproliferative activity against UM cells, leading to cell cycle arrest, apoptosis, and inhibition of migration. Global gene expression profiling revealed strong suppression of genes associated with cell cycle proliferation, DNA replication, and G1/S transition. Gene set enrichment analysis revealed that ICG-001 suppressed Wnt, mTOR, and MAPK signaling. Strikingly, ICG-001 suppressed the expression of genes associated with UM aggressiveness, including CDH1, CITED1, EMP1, EMP3, SDCBP, and SPARC. Notably, the transcriptomic footprint of ICG-001, when applied to a UM patient dataset, was associated with better clinical outcome. Lastly, ICG-001 exerted anticancer activity against a UM tumor xenograft in mice.

2020-04-28 | GSE149417 | GEO

Expression data from AsPC1 cells treated with ICG-001

2014-07-15 | GSE57728 | GEO

Expression data from AsPC1 cells treated with ICG-001

Project description:The CREB binding protein inhibitor ICG-001 suppresses pancreatic cancer growth We used microarrays to detail global gene expression changes in the pancreatic cancer cell line AsPC1 following treatment with ICG-001 or siRNA-mediated knockdown of CTNNB1 (beta-catenin) AsPC1 cells were treated with 10uM ICG-001 or vehicle control (DMSO) for either 6 hours or 24 hours. AsPC-1 cells were also separately transfected with 20nM control siRNA or CTNNB1 siRNA for 48 hours. RNA was extracted at these time points for hybridization to Affymetrix microarrays

2014-07-15 | E-GEOD-57728 | biostudies-arrayexpress

Precise immuno-fluorescence canceling enables highly multiplexed imaging

Project description:Precise immuno-fluorescence canceling enables highly multiplexed imaging

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ICG-001 activates a series of ER stress response genes in monocyte derived macrophages (MDMs)

Project description:By screening a target-focused Wnt-sgnaling small compound library we identified the Wnt-modulator ICG-001 as inihibitory for activating the mitochondrial fission protein Drp1. To explore how ICG-001 might act we undertook gene expression profiling in iCG-001 treated primary macrophages.

2018-01-12 | GSE102117 | GEO

Quantitative ICG Fluorescence Angiography in Colorectal Surgery

Project description:Fluorescence angiography with indocyanine green (ICG-FA) has gained increased popularity in colorectal surgery to check perfusion to the newly-formed anastomotic area and decrease the rate of postoperative anastomotic leakage. While qualitative ICG assessment has the advantage to be used instantly during the operative procedure, it does bear drawbacks (subjective assessment, dependent on factors like camera distance, ICG dose and white-light contamination). The alternative is quantitative ICG assessment, which is performed by evaluating the time-intensity curve of the ICG-FA with an external analyzing software. The procedure is showing promising results, but the methodology is still reported very heterogeneously. This study is a multi-center, prospective, standardized, surgeon-blinded observational trial. The key aspect of this study is the non-interventional design with blinding of both the qualitative and quantitative results from the ICG perfusion measurement, providing no chance of influencing the course of the operation. Assessment of perfusion will be performed postoperatively blinded to the outcome. Assessment of the pre-anastomotic area is intraoperatively performed by an image analysis software that then calculates a perfusion score based on an algorithm integrating relevant perfusion metrics. The primary outcome is the combined rate of early and late anastomotic complications within 90 days postoperatively.

| 2398076 | ecrin-mdr-crc

Indocyanine green fluorescence imaging in liver metastasis from colorectal cancer

Project description:Interventions: A group:Traditional hepatotomy;B group:ICG fluorescence imaging hepatectomy Primary outcome(s): Number of liver lesions detected Study Design: Parallel

| 2699833 | ecrin-mdr-crc

Evaluation of anastomotic blood flow in colorectal surgery using the ICG fluorescence method

Project description:Interventions: Indocyanine green injection at the colorectal surgery Primary outcome(s): Possibility of prediction by evaluation of anastomotic blood flow using the ICG fluorescence method Study Design: Single arm Non-randomized

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