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Evaluation of colorectal anastomotic perfusion by intra-operative transanal ICG infrared fluorescence imaging

ABSTRACT: Interventions: Indocyanine green 0.2mg/kg injection during the colorectal surgery Primary outcome(s): Visibility of anastomotic perfusion Study Design: Single arm Non-randomized

DISEASE(S): Colorectal Cancer

PROVIDER: 2644740 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Evaluation of anastomotic blood flow in colorectal surgery using the ICG fluorescence method

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Perfusion Rate Assessment by Near-infrared Fluorescence in Gastrointestinal Anastomoses

Project description:In this prospective, non-randomized cohort study, real-time intraoperative visualization using near-infrared-fluorescence by indocyanine green injection (ICG-NIRF) is performed at two to three time points during procedures of upper GI, lower GI and hepatobiliary surgery with anastomosis formation in open or laparoscopic surgery. Postoperatively, a detailed software-based assessment of each recording is performed to determine the objective ICG-NIRF perfusion rate before and after anastomosis formation, which is then correlated with the 30 day postoperative clinical outcome including occurrence of anastomotic leak.

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Koeller2021 - PBPK model of ICG liver function tests

Project description:Physiollogically based pharmacokinetic (PBPK) model of indocyanine-green (ICG) liver function tests.

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