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The establishment of diagnosis and endoscopic mucosal resection criteria of early colorectal cancer with premalignant lesion in China

ABSTRACT: Interventions: Gold Standard:;Index test: Primary outcome(s): Invasion depth of colorectal cancer in submucosal layer;Lymph node metastasis Study Design: Diagnostic test for accuracy

DISEASE(S): Colorectal Cancer

PROVIDER: 2662406 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Brain lesion distribution criteria distinguish demyelinating diseases in China.

Project description:ObjectiveTo verify the utility of brain lesion distribution criteria in distinguishing multiple sclerosis (MS) from aquaporin-4 (AQP4)-immunoglobulin G (IgG)-positive/-negative neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein IgG-associated encephalomyelitis (MOG-EM) in the Chinese population.MethodsA total of 253 patients with MS (80), NMOSD (129 AQP4-IgG positive, 34 AQP4-IgG negative), and MOG-EM (10) were enrolled. Anonymized magnetic resonance imaging results were scored on the previous reported criteria of "at least one lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe; or the presence of a subcortical U-fiber lesion; or a Dawson's finger-type lesion." Chi-squared test (or Fisher's exact test) was used to analyze the data.ResultsThe distribution criteria were able to distinguish MS with a same sensitivity of 93.8% from all type of NMOSD and MOG-EM, with a specificity of 89.7% from the whole NMOSD cohort, 89.1% from AQP4-IgG-positive NMOSD 91.2% from AQP4-IgG-negative NMOSD, and 70.0% from MOG-EM. Dawson's finger-type lesion was the most sensitive and specific feature, whereas the U-fiber lesion was the least.ConclusionThe brain lesion distribution criteria were helpful in distinguishing MS from NMOSD and MOG-EM in the Chinese population. Dawson's finger-type lesion was highly suggestive of MS.

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Establishment and Verification of Endoscopic Prediction Model for the Nature and Depth of Invasion of Colorectal Tumors and Exploration of New Diagnostic Methods

Project description:Interventions: Gold Standard:Definite diagnosis by pathology;Index test:Endoscopic Prediction Model for the Nature and Depth of Invasion of Colorectal Tumors and Exploration. Primary outcome(s): Endoscopic characteristics;SEN, SPE, ACC, AUC of ROC Study Design: Sequential

| 2701950 | ecrin-mdr-crc

Project description:test AMX layer

| PRJNA951681 | ENA

Motor cortex after C3 lesion

Project description:Gene expression analysis of motor cortex after spinal C3 lesion Dorsal column wire knife lesions: Adult female Fischer 344 rats weighing 150-200 gm were used. Animals underwent a laminectomy at spinal level C3. Dorsal funiculus lesions were made in the middle of C3 using a Kopf microwire device (Kopf Instruments, Tujunga, CA). After fixation in a spinal stereotaxic unit, a small dural incision was made. The wire knife was lowered into the spinal cord to a depth of 1.1 mm ventral to the dorsal cord surface and 1.1 mm to the left of the midline. The tip of the wireknife was extruded, forming a 2.25 mm-wide arc that was raised to the dorsal surface of the cord. To ensure complete axotomy of the dorsal funiculus, spinal tissue was compressed against the microwire knife surface using a microaspiration pipette until all visible white matter was transected. Cortical microdissection: The forelimb and hindlimb motor cortex were microdisected from rat cortices: Rostral to Bregma: an area from 2.0 to 4.5 mm mediolateral and from 0 to 2 mm anterior-posterior Caudal to Bregma: an area from 2.0 to 3.5 mediolateral and from 0 to 3 mm caudal to Bregma. Only the inferior half of the cortex containing layer V corticospinal motor neurons was sampled in each region.

2016-07-01 | E-GEOD-76679 | biostudies-arrayexpress

Endoscopic Optical Coherence Tomography for Screening and Diagnosis of Colorectal Precancerous and Malignant Polyps

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Magnifying chromoscopic colonoscopy versus endoscopic ultrasonography to predict depth of invasion for early colorectal cancer

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Usefulness of forward-viewing radial-array endoscopic ultrasonography for evaluating invasion depth of colorectal neoplasms

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Endometrial-peritoneal interactions during endometriotic lesion establishment.

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Clinicopathological differences between right and left-sided T1 colorectal cancer

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Clinicopathological differences between small and large T1 colorectal cancer

| 2660159 | ecrin-mdr-crc