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The effect of inflammatory reaction and immune function of immune nutritional on colorectal cancer patients: a prospective study

ABSTRACT: Interventions: A:immune nutrition group;B:General nutrition Fresubin Primary outcome(s): immune indicators;the inflammatory reaction indicators;nutrition indicators Study Design: Randomized parallel controlled trial

DISEASE(S): Colorectal Cancer

PROVIDER: 2675431 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Study about immune nutritional therapy accerlerated rehabilitation after colorectal cancer surgery in the Fast Track model

Project description:Interventions: Group A:Use the conventional enteral nutrition;Group B:Use the immune enhanced enteral nutrition Primary outcome(s): Nutrition Indicators;immune indexes;The acute phase inflammatory reaction index;Barrier function;FT process postoperative rehabilitation index;The safety index FT proces Study Design: Randomized parallel controlled trial

| 2673775 | ecrin-mdr-crc

The impact of fast track model on colorectal cancer patients’ Inflammatory response and immune function after surgery

Project description:Interventions: Group A:Fast track Surgery management mode;Group B:Traditional process management mode Primary outcome(s): inflammatory mediators;Immunological indicators;postoperative rehabilitation index;Postoperative complications Study Design: Randomized parallel controlled trial

| 2675441 | ecrin-mdr-crc

Exploring a novel target of levetiracetam to suppress microglial inflammatory reaction

Project description:Exploring a novel target of levetiracetam to suppress microglial inflammatory reaction

| PRJNA749747 | ENA

Siponimod modulates the reaction of microglial cells to pro-inflammatory stimulation

Project description:Siponimod modulates the reaction of microglial cells to pro-inflammatory stimulation

| PRJNA895428 | ENA

Whole transcriptome analysis reveals a pro-inflammatory profile of ductular reaction cells in AH.

Project description:Objective: Alcoholic hepatitis (AH) is characterized by the expansion of ductular reaction (DR) cells and expression of liver progenitor cell (LPC) markers. The aim of this study was to identify the gene expression profile and associated genes of DR cells and to evaluate its weight in alcoholic disease progression. Design: KRT7+, KRT7- and total liver fractions were laser microdissected from liver biopsies (n=6) of patients with AH and whole transcriptome was sequenced. Gene signature was assessed in transcriptomic data from 41 patients with alcoholic liver disease. Pro-inflammatory profile was evaluated in tissue and serum samples and in human LPC organoids. Results: Transcriptome analysis of KRT7+ DR cells uncovered intrinsic gene pathways of DR and allowed identifying genes associated with DR expressed in AH. In addition, DR gene signature and associated genes correlated with disease progression and poor outcome in AH patients. Importantly, DR presented a pro-inflammatory profile with expression of CXC and CCL chemokines and was associated with infiltrating neutrophils. Moreover, LPC markers correlated with liver expression and circulating levels of inflammatory mediators. In vitro, human LPC organoids mimicked ductular reaction gene expression profile and produced chemokines. Moreover, LPC promoted neutrophil migration and enhanced their inflammatory profile. Conclusions: Here we report for the first time the gene expression signature of DR in AH and its association with disease progression. Functional and experimental analysis demonstrates that DR cells have a pro-inflammatory profile, and suggest their involvement in neutrophil recruitment and liver inflammatory response.

2019-01-11 | GSE100901 | GEO

Clinical study on the relationship between intestinal microflora and malignant tumour immunotherapy response and side effects

Project description:Interventions: Responding group VS Non-response group:N/A;Toxic side reaction group VS non-toxic side reaction group:N/A Primary outcome(s): Intestinal flora;blood count;Immunological indicators;Inflammatory indicators Study Design: Factorial

| 2695074 | ecrin-mdr-crc

Epithelial-Immune Metabolic Codependency Fuels Inflammatory Disease

Project description:Epithelial-Immune Metabolic Codependency Fuels Inflammatory Disease

| PRJNA996582 | ENA

Effect of Ginsenoside Rb1 on inflammatory reaction and odontogenic differentiation of human dental pulp cell

Project description:Effect of Ginsenoside Rb1 on inflammatory reaction and odontogenic differentiation of human dental pulp cell

| PRJNA1076132 | ENA

Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice

Project description:Excessive sulfur oxidation in endoplasmic reticulum drives an inflammatory reaction of chondrocytes in aging mice

2022-10-12 | PXD037302 |

Polypropylene mesh implantation for hernia repair triggers myeloid cell-dependent persistent inflammatory foreign body reaction

Project description:Polypropylene meshes that are commonly used for surgical groin hernia repair may trigger granulomatous foreign body reactions. Here, we show that asymptomatic patients display mesh-associated inflammatory granulomas long after surgery, which are dominated by monocyte-derived macrophages. In mice, subdermal mesh implantation induces a rapid and strong myeloid cell accumulation, without substantial attenuation for up to 90 days. Myeloid cells segregate into distinct macrophage subsets with separate spatial distribution, activation profiles and functional properties. Protein mass spectrometry confirms the inflammatory nature of the foreign body reaction, as characterized by cytokines, complement activation and immunoglobulin deposition.

2019-01-24 | PXD009944 | Pride

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