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Effects of TAPB and flurbiprofen axetil on postoperative recovery in elderly patients undergoing colorectal surgery: a randomized, controlled trial of 2x2-factorial design

ABSTRACT: Interventions: TAPB:continue TAPB perioperaitive;The flurbiprofen group:Continuous infusion of flurbiprofen by postoperative analgesic pump;TAPB+flurbiprofen group:Continuous intraoperative and postoperative TAPB and continuous intravenous analgesic pump infusion of flurbiprofen Primary outcome(s): The incidence of chronic pain after operation;Incidence of postoperative cognitive dysfunction Study Design: Case-Control study

DISEASE(S): Colorectal Neoplasms

PROVIDER: 2680085 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Effect of Remimazolam Co-induction and Maintenance on Postoperative Delirium In Older Patients Undergoing undergoing laparoscopic surgery: A Randomized Controlled Clinical Trial

Project description:Interventions: R Group:Anesthesia was induced and maintained by continuous intravenous pump injection of propofol remazolam.;P Group:Anesthesia was induced and maintained by continuous intravenous pump injection of propofol Primary outcome(s): Incidence of delirium within 3 days after surgery;Cognitive function status Study Design: Parallel

| 117063 | ecrin-mdr-crc

Protective effects of INSL6 on heart failure

Project description:Background: The insulin/IGF/relaxin family represents a group of structurally related but functionally diverse proteins. The family member Relaxin-2 has been evaluated in clinical trials for its efficacy in the treatment of acute heart failure. In this study, we assessed the role of Insulin-like peptide 6 (Insl6), another member of this protein family, in murine heart failure models using genetic loss-of-function and protein delivery methods. Methods and Results: Insl6-deficient (Insl6-KO) and wild-type (C57BL/6N) mice were administered angiotensin II or isoproterenol via continuous infusion with an osmotic pump or via intraperitoneal injection once a day, respectively for 2 weeks. In both models, Insl6-KO mice exhibited greater cardiac systolic dysfunction and left ventricular dilatation hypertrophy. Cardiac dysfunction in the Insl6-KO mice was associated with more extensive cardiac fibrosis and greater expression of fibrosis-associated genes. The continuous infusion of chemically synthesized INSL6 significantly attenuated left ventricular systolic dysfunction and cardiac fibrosis induced by isoproterenol infusion. Gene expression profiling suggests Lxr/ Rxr signaling is activated in the isoproterenol-challenged hearts treated with INSL6 protein. Conclusions: Endogenous Insl6 protein inhibits cardiac systolic dysfunction and cardiac fibrosis in angiotensin II- and isoproterenol-induced cardiac stress models. The administration of recombinant Insl6 protein could have utility for the treatment of heart failure and cardiac fibrosis.

2018-05-31 | GSE102612 | GEO

Efficacy of systemic lidocaine on quality of recovery in patients undergoing colorectal endoscopic submucosal dissection

Project description:Interventions: lidocaine group:Patients received an intravenous bolus injection of lidocaine 1.5 mg/kg over 10 min before induction of anesthesia, followed by a continuous infusion of 2 mg/kg/h until the end of the surgery.;control group:Patients received a perioperative 0.9% saline infusion at the same rate as the lidocaine infusion. Primary outcome(s): Incidence of postoperative cognitive recovery Study Design: Parallel

| 35544 | ecrin-mdr-crc

Hippocampal single-cell atlas screening unveils disrupted neuroglial system in postoperative cognitive impairment

Project description:This study investigates the roles of neurons, microglia, astrocytes, and oligodendrocytes in the pathogenesis of postoperative cognitive impairment, focusing on a dysregulated glia-neuron cycle. We utilized 18-month male C57BL/6 mice to model this condition, conducting single-cell RNA sequencing in the hippocampus to explore the neuroglial interactions and their implications in neuroinflammation, synaptic dysfunction, and myelin loss. This dataset includes transcriptomic profiles aimed at decoding the cellular communication in aged hippocampal cells and assessing the impact of therapeutic interventions on postoperative cognitive decline.

2024-11-14 | GSE267933 | GEO

Circular RNAs Expression in Elderly Patients with Postoperative Cognitive Dysfunction

Project description:Circular RNAs Expression in Elderly Patients with Postoperative Cognitive Dysfunction

| PRJNA613660 | ENA

Complement C3 released from neurotoxic reactive astrocytes impairs learning and memory in the mouse model of postoperative neurodegenerative disorders

Project description:Perioperative neurocognitive disorder (PNDs) can commonly occur after major surgery in at risk patients and its occurrence increases medical healthcare burdens and even mortality. Accumulating evidence points to neuroinflammation being pivotal to the pathogenesis of these conditions. The complement cascade contributes to neuroinflammatory responses in the central nervous system (CNS) and complement C3 has been implicated in the manifestation of cognitive deficits in several neurological conditions. Neurotoxic reactive astrocytes function differently to their non-activated counterparts and release complement components in response to pathological triggers. We observed previously that surgery induces a rapid rise and then fall in cytokines but a more sustained glial activation response that coincided with postoperative cognitive impairment. In this study, we explored the relationship between the expression of complement C3, glial activation, and cognitive deficits. Using a murine model of surgery, we characterized the transcriptional profiles of hippocampal astrocytes after surgery and examined the effects of C3 suppression on the neuroinflammatory response and cognitive performance. There was a delayed but sustained rise in hippocampal C3 of astrocytic in origin after surgery which corresponded with the onset of cognitive decline. Furthermore, the A1 or the neurotoxic phenotype predominated in this postoperative astrocytic activation, and these cells have a distinct transcriptional profile including C3 upregulation. Suppression of C3 inhibited synaptic phagocytosis by microglia and attenuated postoperative cognitive impairment. Therefore, C3 from reactive astrocytes appear central to the development of cognitive dysfunction associated with postoperative neuroinflammation.

2024-03-13 | GSE199318 | GEO

Transcription profiling of mouse to predict left ventricle systolic dysfunction using gene expression profiling

Project description:We tested the hypothesis that a set of differentially expressed genes could be used to predict cardiovascular phenotype in mice after prolonged catecholamine stress. Experiment Overall Design: We observed that WT FVB and B2KO mice developed systolic dysfunction in response to continuous catecholamine infusion while WT C57 mice developed diastolic dysfunction. Using these mice as the derivation cohort, we identified a set of 83 genes whose differential expression correlated with left ventricle systolic dysfunction. The gene set was then used to accurately predict development of left ventricle systolic dysfunction in a separate group of mice (WT B6129SF2/J) after catecholamine stress.

2009-10-26 | E-GEOD-12413 | biostudies-arrayexpress

Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery

Project description:Objectives: To compare free-opioid anesthesia (the combination of epidural anesthesia, intravenous lidocaine, ketamine, propofol, and sevoflurane) and opioid anesthesia (fentanyl, propofol and sevoflurane) regarding intraoperative analgesic efficacy in colectomies and rectal resections at Viet Tiep Friendship Hospital. Methods: A prospective, randomized controlled clinical trial was performed on 98 patients who were anesthetized for colorectal surgery from December 2019 to November 2021. Patients were randomized into 2 groups: Group OA - Opioid anesthesia (n = 49): Intraoperative pain control by fentanyl; FOA group - Free-opioid anesthesia (n = 49): Intraoperative pain control by continuous infusion of lidocaine, bolus doses of ketamine combined with epidural levobupivacaine.

| 92384 | ecrin-mdr-crc

A pilot study of ex vivo human prefrontal RNA transcriptomics in Parkinson’s disease

Project description:Parkinson’s disease (PD) can dramatically change cortical neurophysiology. The molecular basis for PD-related cortical changes is unclear because gene expression data are usually derived from postmortem tissue collected at the end of a complex disease and they profoundly change in the minutes after death. Here, we studied cortical changes in tissue from the prefrontal cortex of living PD patients undergoing deep-brain stimulation implantation surgery. We examined 780 genes using the NanoString nCounter platform and found that 40 genes were differentially expressed between PD (n = 12) and essential tremor (ET; n = 9) patients. One of these 40 genes, STAT1, correlated with intraoperative 4-Hz rhythms and intraoperative performance of an oddball reaction-time task. Using a pre-designed custom panel of 780 targets, we compared these intraoperative data with those from a separate cohort of fresh-frozen tissue from the same frontal region in postmortem human PD donors (n = 6) and age-matched neurotypical controls (n = 6). This cohort revealed 279 differentially expressed genes. Fifteen of the 40 intraoperative PD-specific genes overlapped with postmortem PD-specific genes, including CALB2 and FOXP2. Transcriptomic analyses identified pathway changes in PD that had not been previously observed in postmortem cases. These molecular signatures of cortical function and dysfunction may help us better understand cognitive and neuropsychiatric aspects of PD.

2023-03-27 | GSE227990 | GEO

m6A RNA methylation profiling in hippocampus of POCD mice induced by sevoflurane

Project description:Elderly patients are apt to cognitive impairment and memory loss after surgical operations. This perioperative cerebral damage named postoperative cognitive dysfunction (POCD) is profoundly affected by anesthesia. N6-methyladenosine (m6A) RNA methylation as a widely-studied epigenetic modification to regulate gene expression, however, is never studied in POCD. Initially, fifty 40-week-old outbred female C57BL/6 mice were conducted Morris water maze test by EthoVision XT working system (Noldus, Netherlands) as manufacturer’s instructions. The escaping latent period of each mouse were recorded. Then Thirty mice were randomly selected and given 2% sevoflurane for 4 h in an automatic anesthetic chamber with size of 24 cm*12 cm*18 cm. After natural resuscitation, POCD and non-POCD mice were picked up based on the dynamics of escaping latent period. The other twenty mice received normal air were treated as negative control. Hippocampus were conducted RIP-seq for investigating m6A RNA methylation.

2021-05-31 | E-MTAB-10510 | biostudies-arrayexpress

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