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Evaluating the efficacy and safety of L-Arabic syrup in bowel preparation: a multicenter prospective randomized controlled trial

ABSTRACT: Interventions: experiment group:L-Arabinose syrup;control group:PEG-ELP (IV) Primary outcome(s): the rate of adequate bowel preparation based on BBPS scale Study Design: Parallel

DISEASE(S): Colorectal Neoplasms

PROVIDER: 2703619 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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infectious surgical site complications after oral antibiotic bowel preparation for minimally-invasive rectal cancer surgery

Project description:Interventions: Drug : 1. experimental group (A) - mechanical bowel preparation (PEG) + IV antibiotics 2. control group (B) - mechanical bowel preparation (PEG) + IV antibiotics + oral antibiotics (rifaximin + metronidazole) 3. pre-operative preparation 3.1. mechanical bowel preparation - PEG prefered - water only permitted on the day before operation 3.2. oral antibiotics - 14, 16, 22 hour the day before surgery - 400mg rifaximin + 500mg metronidazole 3.3. IV antibiotics - 2nd generation cephalosporin - venous injection within 30 minutes before surgery - additional dose is at the discretion of the operators Primary outcome(s): surgical site infection rate during first 30 days Primary Purpose : Prevention, Intervention Model : Factorial, Blinding/Masking : Open, Allocation : RCT

| 2512754 | ecrin-mdr-crc

Comparative study on the effects of oral and microscopic spraying of simethicone in bowel preparation

Project description:Interventions: experiment group:PEG orally + endoscopic spraying simethicone oil;control group:simethicone oil combined with PEG orally;control group2:Oral PEG Primary outcome(s): the quality of bowel cleansing;adenoma detection rate;Intestinal bubble grading Study Design: Parallel

| 2704108 | ecrin-mdr-crc

Effect of Simethicone on Bowel Preparation for Colonoscopy

Project description:Optimal bowel preparation is essential for colonoscopy efficacy and safety. Mucosal visualization during colonoscopy is often limited by residual stool, bubbles, bile, intraluminal fluid, and debris, which increase the risk of missing flat adenomas or other small lesions.Therefore, intestinal preparation is necessary to remove residual materials prior to endoscopy. A combined agent, low-dose PEG with ascorbic acid (PEG-Asc), is one low-volume solution commonly used in Korea (Coolprep; TaeJoon Pharmaceuticals, Seoul, Korea). However, practitioners have noted an increased incidence of bubble formation with this preparation method. To the investigators knowledge, no previous study has assessed colon preparation in patients administered simethicone. The purpose of this study was to compare the quality of bowel preparation and compliance between PEG-Asc and PEG-Asc with simethicone. The effectiveness of adding simethicone as an antifoaming agent to improve bowel cleansing for colonoscopy was evaluated in terms of bowel preparation scale and bubble score, and the compliance of both patients and endoscopists was also investigated using a questionnaire.

| 2198002 | ecrin-mdr-crc

Evaluation of Reduced-volume PEG Bowel Preparation Administered the Same Day of Colonoscopy

Project description:The conventional total dose of 4 L of polyethylene glycol (PEG) given the day before the procedure is safe and effective. It has been the standard cleansing regimen for the last 25 years. To overcome the difficulty in completing the bowel preparation due to large volume and/or taste, reduced-volume (mixed) bowel preparation of bisacodyl and 2 L of PEG have been shown to provide adequate colon cleansing and better tolerability. LoVol-esse is a reduced-volume PEG-based bowel preparation to be used in combination with bisacodyl and designed to improve patient tolerability and attitude toward bowel cleansing prior to colonoscopy thanks to the reduced volume and improved taste. The present study is intended to compare the new dosing regimen of the bowel lavage solution given the same day compared with standard PEG formulation (SELG 1000) given the day before colonoscopy.

| 2120359 | ecrin-mdr-crc

Evaluating bias-reducing protocols for RNA sequencing library preparation

Project description:Evaluating bias-reducing protocols for RNA sequencing library preparation

| PRJEB6271 | ENA

Anaerobic preparation study

Project description:Anaerobic preparation study

| PRJEB64928 | ENA

A controlled study of efficacy and safety in CT colonography preparation with Mosapride Citrate Hydrate

Project description:Interventions: Polyethylene glycol lavage solution plus contrast medium (PEG-C) preparation before CT colonography Polyethylene glycol lavage solution plus contrast medium and Mosapride Citrate Hydrate (PEG-CM) preparation before CT colonography Primary outcome(s): PEG-C versus PEG-C + Mosapride Citrate Hydrate for bowel preparation before CT colonography to be asscessed by the amount of residual fluid. Study Design: Parallel Randomized

| 2620536 | ecrin-mdr-crc

Effect of Adding Simethicone to Split-dose Polyethylene Glycol for Bowel Preparation in a Screening Colonoscopy Setting

Project description:Colonoscopy is currently accepted as the gold standard in screening, surveillance and prevention for colorectal cancer (CRC), and therefore, its quality is a major priority. The quality of colonoscopy is greatly dependent on the quality of the bowel preparation. Standard bowel cleansing includes a low-fibre diet on the day preceding the exam and a split regimen of 4 litres of polyethylene glycol (PEG) solution. In order to improve bowel cleansing some additional measures are available. Simethicone is an inexpensive and safe antifoaming agent that reduces the surface tension of air bubbles, theoretically presenting several benefits such as increased tolerability to the preparation, thereby improving the quality of the preparation and, secondly, adenoma detection (ADR) and cecal intubation rates (CIR). However, its role remains controversial, with some publications supporting its administration and others failing to demonstrate clear benefits. The main aim of this study is to assess if addition of simethicone to a split-dose cleansing regimen of 4 litres of PEG improves adequate bowel preparation rate.

| 2295328 | ecrin-mdr-crc

Efficacy of 2-Liter Mixed Preparation With Bisacodyl Plus Polyethylene Glycol and 4-Liter Polyethylene Glycol for Colon Cleansing in Patients With Prior History of Colorectal Resection

Project description:Studies that have investigated different bowel preparations in patients with history of colorectal surgery are surprisingly lacking.Therefore, which is the best colon preparation in this subgroup of patients is still unknown. Polyethylene glycol (PEG)-based solutions are the most popular and safest bowel preparation regimens, however the 4-Liter volume is often poorly tolerated. More recently, it has been shown that the use of a low volume preparation (2-Liter PEG solution with the adjunct of a laxative, bisacodyl) achieves comparable bowel cleanliness rates to 4-Liter PEG in general population.The primary aim will be to compare the efficacy of 2-L mixed preparation (bisacodyl plus PEG) to 4-L PEG preparation.

| 2147376 | ecrin-mdr-crc

Combination Lubiprostone and Split-Dose PEG-ELS Vs Split-Dose PEG-ELS alone for bowel preparation before colonoscopy in constipated patients: A prospective, endoscopist-blinded, randomized controlled trial

Project description:Interventions: split-dose PEG-ELS combination with Lubiprostone 3 times by specifying as follows; 2 days before colonoscopy 1 capsule of Lubiprostone at 6.00 a.m. then took 1 capsule of Lubiprostone at 6 p.m. Day before colonoscopy - 1 capsule of Lubiprostone at 6.00 a.m. The subjects would receive 1 sachet of PEG-ELS mixed with 2 liters of water, which the patients had to take all within 2 hours at 6:00 p.m. Lastly, on the colonoscopy day, the subjects received 1 sachet of PEG-ELS mixed with 2 liters of water and took it all in 2 hours at 4.00 a.m. on the day of the colonoscopy.,split-dose PEG-ELS before colonoscopy day, patients had to take 1 sachet of PEG-ELS with 2 Liter of water at 6 p.m. and 1 sachet of PEG-ELS with 2 Liter of water at 4 a.m. on the day of the colonoscopy.;Active Comparator Drug,Placebo Comparator Drug;split-dose PEG-ELS combination with Lubiprostone 3 times ,split-dose PEG-ELS combination Primary outcome(s): the Ottawa bowel preparation score Colonoscopy day proportion of adequate bowel cleansing Study Design: Randomized

| 56421 | ecrin-mdr-crc

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