Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Underwater ESD vs Conventional ESD for SCN

ABSTRACT: Interventions: Procedure/Surgery : underwater endoscopic submucosal dissection - after submucosal injection, partial circumferential submucosal incision around the superficial colorectal neoplasia, and then conducted submucosal dissection with water pressure assisted traction on underwater conventional endoscopic submucosal dissection - after submucosal injection, partial circumferential submucosal incision around the superficial colorectal neoplasia, and then conducted submucosal dissection Primary outcome(s): procedure time (measured as the time from the submucosal injection to complete removal of the superficial colorectal neoplasia based on endoscopic assessment) Primary Purpose : Treatment, Intervention Model : Parallel, Blinding/Masking : , Blinding Target : Subject, Allocation : RCT

DISEASE(S): Diseases Of The Digestive System

PROVIDER: 2727762 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

ACCESS DATA

Json Xml

Similar Datasets

Evaluation of Endoscopic Submucosal Dissection (ESD) Efficacy

Project description:Superficial rectal tumors could be removed by ESD with two major advantages showed by the literature: high rate of monobloc resection and R0 resection. Hence, recurrence rate was lower than ERM therapy. This technique is actually performed routinely in Japan and experience is limited in Europe, with few data in the literature. This study is suggested to patients with superficial medium or distal rectal tumors. The lesion was identified and demarcated using white-light endoscopy, magnifying endoscopy, and chromoendoscopy. Then, marking around the lesions was performed. Local injection was made using injection needle, and then mucosal incision was performed around the lesion using endo-knives. Submucosal dissection was performed using endo-knives. Hemostasis and vessel coagulation were practiced using primary hemostatic forceps during the procedure. Follow-up is one year. For lesion with invasive carcinoma (vessel and lymphatic involvement, undifferentiated, free margin less than 1 mm), a surgical resection is performed. All the patients have an endoscopic control 3 months after ESD (rectosigmoidoscopy with biopsies): * For complete resection, an endoscopic control was performed at 1 year. * For incomplete resection, another endoscopic therapy was attempted (EMR) an endoscopic control was performed at 1 year. At one year, patient with incomplete resection have a surgical resection.

| 2146818 | ecrin-mdr-crc

Tapered Tip Hood with an Air Bubble Outlet in Underwater Colorectal ESD: A Prospective Study

Project description:Interventions: Underwater endoscopic submucosal dissection using a tapered tip hood with an air bubble outlet Primary outcome(s): Rate of hood-use completion Study Design: single arm study, open(masking not used), uncontrolled control, single assignment, treatment purpose

| 2614769 | ecrin-mdr-crc

French Colorectal ESD Cohort in Experts Centers

Project description:Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single fragment. It allows a perfect pathological analysis, and decreases the rate of recurrence of the adenoma to less than 2%. However, this procedure, which is technically more challenging, is also more risky (perforation rate at 4% vs. 1% for WF-EMR) and longer. Submucosal dissection is also more expensive in terms of equipment, but this difference can be offset by the cost of the high number of iterative colonoscopies required in patients who have had endoscopic resection by WF-EMR. Scientific debate is agitating the Western world1,2 and Japanese experts do not perform WF-EMR anymore, whereas no comparative prospective study has compared these two procedures. A lot of centers in France performed colorectal ESD even for benign lesions and nationwide data about safety and efficiency is required to confirm the place of ESD for treatment of large superficial colorectal lesions.

| 2354874 | ecrin-mdr-crc

To investigate the standard programme of endoscopic submucosal tunnelling (ESDTT) and conventional endoscopic submucosal dissection (ESD) for the treatment of early esophagus, stomach, colorectal cancer and precancerous lesions

Project description:Interventions: Group 1:endoscopic submucosal tunnel dissection;Group 2:Routine endoscopic submucosal dissection Primary outcome(s): En bloc dissection;R0 resection rate;curative resection rate;Dissection speed Study Design: Non randomized control

| 2669338 | ecrin-mdr-crc

Endoscopic resection for laterally spreading tumor (LST) -(endoscopic submucosal dissecion (ESD) vs. endoscopic mucosal resection)-

Project description:Interventions: Group A. ESD group 1. The solution of a mixture of Glyceol and 1% 1900-KDa hyaluronic acid preparation is injected into the submucosal layer. 2. Mucosal incision is started with the knife for ESD. 3. The lesion is resected with submucosal dissection. Group B. EMR group 1. The solution of normal saline is injected into the submucosal layer. 2. The lesion is resected with an electrosurgical snare. Primary outcome(s): the incidence of local recurrence after endoscopic resection Study Design: Parallel Randomized

| 2616263 | ecrin-mdr-crc

Endoscopic Sub-mucosal Dissection With the Nestis Jet Injector System With a Bi-functional Catheter: First Prospective Trial

Project description:ESD (Endoscopic Sub-mucosal Dissection)is the first-intent method to treat superficial neoplasms of the digestive tract at it allows an en-bloc R0 resection. Following marking of the lesion margins, ESD comprises 3 steps: 1) liquid injection into the sub-mucosal space 2) circumferential (complete or partial) incision and 3) dissection of the submucosa. Several tools are necessary to perform ESD with the standard technique. Development of water jet with bi functional (injection and cutting) catheter allows time and significant reduction of perforation risk (due to multiple changes of instruments). For this purpose, Nestis introduced the Enki 2 pulsed jet technology with high pressure system to inject efficiently and at any time viscous solutions in direct viewing and retroflexion. Preliminary pig studies indicate that injection of glycerol, hyaluronate and hydroxyethlstarch with Enki 2 are possible. In addition, preclinical studies on living pig colon models using saline solutions have demonstrated that perforation rates and operating times are significantly reduced compared to a standard electrosurgical knife. The present clinical study is being performed to confirm this system capability to perform ESD in humans.

| 2149365 | ecrin-mdr-crc

Outcomes of Perforation After Colorectal Endoscopic Submucosal Dissection

Project description:Endoscopic resection of superficial colorectal neoplasms decrease risk of colorectal cancer. En bloc resection is necessary for large superficial lesions with risk of superficial submucosal cancer and is advised if feasible for all lesions. Endoscopic submucosal dissection (ESD) allows en bloc resection of large superficial colorectal neoplasms, increasing curative resection rate and decreasing local recurrence risk. However, the risk of perprocedural or delayed perforation is higher compared to wild field piece meal endoscopic mucosal resection. Endoscoping clipping and closing methods mostly allow conservative treatment, but some case still necessitate surgery. The aim of our study is to describe and ananalyse outcomes after perprocedural or delayed perforation in all patients undergoing ESD and analyse the need for surgical intervention.

| 8389 | ecrin-mdr-crc

Prospective Evaluation of the Efficacy and Safety of Submucosal Endoscopy

Project description:To test the idea that submucosal endoscopy is effective and safe for endoscopic myotomy, endoscopic submucosal dissection, and access for tissue acquisition and resection. Submucosal endoscopy is a recent innovative addition to gastrointestinal endoscopy. This involves endoscopic maneuvers in the gut wall, by dissection of the submucosal layer of GI tract, thereby allowing endoscopic myotomy (incision of the muscle), endoscopic access for tissue acquisition and therapy, and resection of precancerous and cancerous gastrointestinal tissue. This approach has been a dramatic game-changer for minimally invasive management of various gastrointestinal conditions such as Zenker’s diverticulum, Achalasia, Spastic Esophageal Disorders, Gastroparesis, esophageal obstruction, Hirschsprung’s Disease, and Gastrointestinal neoplasia. The aim of the proposed study is to prospectively assess technical success, clinical success, and adverse events after submucosal endoscopy. Technical success will be defined as ability to successfully complete the submucosal endoscopic procedure. Clinical success will be defined as symptom relief and objective evaluation which will be assessed with radiologic imaging, repeat endoscopy, gastrointestinal motility studies, and pathology results routinely performed post-procedure for clinical care, as indicated. Adverse events will be recorded per published ASGE criteria. A database/ registry of patients undergoing submucosal endoscopic procedures will be created to demonstrate this.

| 2280699 | ecrin-mdr-crc

Multicentric Study an Endoscopic Treatment of Digestive Neoplasia by Submucosal Dissection Evaluation of a New Water Jet System

Project description:safety evaluation of endoscopic sub-mucosal dissection with nestis enki2 system. This system is a new water jet system which allows to perform Endoscopic submucosal dissection with a bifunctional catheter (injection and cutting).

| 2149194 | ecrin-mdr-crc

Performance of Preoperative Antibiotics for Post-ESD coagulation syndrome

Project description:Interventions: Antibiotics Without antibiotics Primary outcome(s): The rate of post electrocoagulation syndrome after colorectal endoscopic submucosal dissection Study Design: Parallel Randomized

| 2650247 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data