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Electroacupuncture intervention for gastrointestinal dysfunction after chemotherapy in colorectal cancer: a randomized controlled trial

ABSTRACT: Interventions: Acupuncture group:Acupuncture;Sham acupuncture group:Sham acupuncture ;Waiting list group:None Primary outcome(s): Gastrointestinal symptom rating scale Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 41398 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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A randomized controlled trial on the effectiveness and safety of acupuncture in the treatment of gastrointestinal dysfunction after chemotherapy for colorectal cancer

Project description:Interventions: Acupuncture group:Acupuncture;Sham acupuncture group:Sham acupuncture;Waiting list group:No Primary outcome(s): Gastrointestinal symptom rating scale Study Design: Parallel

| 2759137 | ecrin-mdr-crc

Clinical randomized controlled pilot trial of acupuncture on gastrointestinal dysfunction after colorectal cancer surgery

Project description:Interventions: Acupuncture group:electric acupuncture plus routine therapy;Sham acupuncture group:sham electric acupuncture plus routine therapy;Conventional treatment group:routine therapy Primary outcome(s): Gastrointestinal symptom rating scale Study Design: Parallel

| 35512 | ecrin-mdr-crc

Electro-acupuncture for postoperative gastrointestinal dysfunction in colorectal cancer: a randomized controlled trial

Project description:Interventions: Electro-acupuncture group:Electro-acupuncture;Sham electro-acupuncture group:Sham electro-acupuncture;Routine group:Routine therapy Primary outcome(s): The time of first postoperative anal exhaust Study Design: Parallel

| 41280 | ecrin-mdr-crc

Transcript Profiling of Arcuate Nucleus in Response to Electroacupuncture on Rats

Project description:The electroacupuncture-induced analgesic effect has been used widely to alleviate diverse pains. However, significant individual variations in analgesic effect of EA for both experiments and clinics were reported. According to the sensitivity of the analgesic response to EA stimulation, the subjects could be categorized into high responders (HR) and non responders (NR). However, the molecular mechanism of individual variability in the analgesic response to acupuncture stimulation is still uncertain. This study aims to investigate the potential gene expression in arcuate nucleus induced by 2Hz/100Hz electroacupuncture in HR and NR rats. Rats were given 2Hz or 100Hz electroacupuncture for 30 min and using cDNA microarrays to compare different gene expression in arcuate nucleus. Rats were exposed to different frequencies (2Hz or 100Hz) electroacupuncture stimulation for 30 min and nociceptive testing and returned to home cages for 1 hour before sacrificed. According to the sensitivity of the analgesic response to 2Hz or 100Hz EA stimulation, the rats divided into four groups: 2Hz-HR group, 2Hz-NR group, 100Hz-HR group and 100Hz-NR group. Subsequently analyzed their dorsal horn transcript profile using cDNA microarrays, the rats were without receiving electroacupuncture as control. The tissue of arcuate nucleus (Arc) of three rats was selected for transcript analysis in each group. The three control rats were mixed and labeled with cy5, each rat of experiment groups was labeled with cy3.

2011-07-07 | E-GEOD-30365 | biostudies-arrayexpress

Electroacupuncture Alleviates Perioperative Hypothalamus-Pituitary-Adrenal Axis Dysfunction via CircRNA-miRNA-mRNA Networks [mRNA]

Project description:Electroacupuncture (EA) has long been used to treat surgery-induced hypothalamic-pituitary-adrenal (HPA) axis dysfunction. However, its target gene expression profiles in the brain remain unclear. Thus, the aim of the present study was to clarify the potential targets of EA based on RNA sequencing techniques (RNA-seq). Rats were randomly divided into normal control, hepatectomy surgery (HT), HT+EA, and HT+sham EA groups followed by RNA-seq of two representative nuclei in the hypothalamus and amygdala.

2023-03-02 | GSE214278 | GEO

Electroacupuncture Alleviates Perioperative Hypothalamus-Pituitary-Adrenal Axis Dysfunction via CircRNA-miRNA-mRNA Networks [miRNA]

2023-03-02 | GSE214277 | GEO

Electroacupuncture Alleviates Perioperative Hypothalamus-Pituitary-Adrenal Axis Dysfunction via CircRNA-miRNA-mRNA Networks [circRNA]

2023-03-02 | GSE214276 | GEO

Gene expression data from striatal regions of MPTP-intoxicated mouse brain by acupuncture

Project description:Acupuncture at acupoints GB34 and LR3 has been reported to inhibit nigrostriatal degeneration in parkinsonism models, yet the genes related to this preventive effect of acupuncture on the nigrostriatal dopaminergic system remain elusive. We investigated gene expression profile changes in the striatal region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism models after acupuncture at the acupoints GB34 and LR3 C57BL/6 mice were divided into four experimental groups; â C: Control, â¡ M: MPTP-treatment only, â¢ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, â£ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from two brains' striatal regions of each experimental group (4 experimental group Ã 2 samples of each experimental group = total 8 samples).

2010-10-23 | E-GEOD-24829 | biostudies-arrayexpress

SAGE Profiles of Rat Lung Tissues

Project description:Thirty-two SD rats (male, 150 grams, 50days) were randomly divided into four groups: normal control group, asthma group, acupuncture-treated asthma group and acupuncture-treated normal group. The rat lungs were removed immediately after the rats were died. The rat lungs were conserved in liquid nitrogen. SAGE analyses were dependent on the classic protocol (Velculescu VE, et al, Serial Analysis of Gene Expression Detailed Protocol, version 1.0e, 2000) available at the SAGENET website. Keyword = Rat Keyword = Lung Keyword = Asthma Keyword = SAGE Keyword = Acupuncture Keywords: disease state analysis

2005-04-09 | GSE2475 | GEO

Gene expression data from thalamic regions of MPTP-intoxicated mouse brain by acupuncture

Project description:Acupuncture stimulations at GB34 and LR3 inhibit the reduction of tyrosine hydroxylase in the nigrostriatal dopaminergic neurons in the parkinsonism animal models. Especially, behavioral tests showed that acupuncture stimulations improved the motor dysfunction in a previous study. The thalamus is a crucial area for the motor circuit and has been identified as one of the most markedly damaged areas in Parkinson’s disease (PD), so acupuncture stimulations might also have an effect on the thalamic damage. We investigated gene expression profile changes in the thalamic region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism models after acupuncture at the acupoints GB34 and LR3 C57BL/6 mice were divided into four experimental groups; ① C: Control, ② M: MPTP-treatment only, ③ MA: MPTP- and acupuncture-treatment at acupoints GB34 and LR3, ④ MNA: MPTP- and acupuncture-treatment at non-acupoints. Total RNA was isolated from two brains' thalamic regions of each experimental group (4 experimental group × 2 samples of each experimental group = total 8 samples).

2012-01-18 | E-GEOD-35138 | biostudies-arrayexpress

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