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Construction and application of an evidence-based temporary enterostomy health education

ABSTRACT: Interventions: Control Group:Provide routine health education during the period from temporary enterostomy surgery to stoma return surgery;Observation Group:On the basis of routine health education, apply the Skinner program teaching method to provide health education for patients. Primary outcome(s): Enterostomy patients self-management questionnaire;the Chinese Caregiver Preparedness Scale Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 87137 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Effectiveness of a design thinking-based health education program intervention for patients with temporary enterostomies: a randomized controlled trial

Project description:Interventions: Experimental group:Health education using the Health Education Program for Patients with Temporary Enterostomy developed in advance;Control group:General Health Education Primary outcome(s): Self-care capabilities of patients with stoma;Incidence of stoma-related complications Study Design: Parallel

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Diagnosis of Taenia solium infections based on “mail order” RNA-sequencing of single tapeworm egg isolates from stool samples

Project description:Combined community health programs aiming at health education, preventive antiparasitic chemotherapy, and vaccination of pigs have proven their potential to regionally reduce and even eliminate Taenia solium infections that are associated with a high risk of neurological disease through ingestion of T. solium eggs. Yet it remains challenging to target T. solium endemic regions precisely or to make exact diagnoses in individual patients. One major reason is that the widely available stool microscopy may identify Taenia ssp. eggs in stool samples as such, but fails to distinguish between invasive (T. solium) and less invasive Taenia (T. saginata, T. asiatica, and T. hydatigena) species. The identification of Taenia ssp. eggs in routine stool samples often prompts a time-consuming and frequently unsuccessful epidemiologic workup in remote villages far away from a diagnostic laboratory. Here we present “mail order” single egg RNA-sequencing, a new method allowing the identification of the exact Taenia ssp. based on a few eggs found in routine diagnostic stool samples. We provide first T. solium transcriptome data, which show extremely high mitochondrial DNA (mtDNA) transcript counts that can be used for subspecies identification. “Mail order” RNA-sequencing can be administered by health personnel equipped with basic laboratory tools such as a microscope, a Bunsen burner, and access to an international post office for shipment of samples to a next generation sequencing facility. Our suggested workflow combines traditional stool microscopy, RNA-extraction from single Taenia eggs with mitochondrial RNA-sequencing, followed by bioinformatic processing with a basic laptop computer. The workflow could help to better target preventive healthcare measures and improve diagnostic specificity in individual patients based on incidental findings of Taenia ssp. eggs in diagnostic laboratories with limited resources.

2021-11-06 | GSE175668 | GEO

Integrative Proteome, Transcriptome and DNA Methylome Analysis of Regulatory Networks During U937-derived Macrophage Polarization from an M2 to M1 Phenotype [array]

Project description:Tumor associate macrophages (TAMs) depletion or re-education towards an antitumor effector phenotype are considered a promising cancer therapeutic approach. However, the underlying molecular mechanisms remain unclear. Here, we apply proteome, transcriptome and DNA methylome to assay the regulatory networks during polarization of U937-derived macrophages transitioning from an M2 to M1 phenotype.

2021-08-18 | GSE127981 | GEO

Cross-sectional association of salivary proteins with age, sex, body mass index, smoking, and education

Project description:In a cross-sectional approach, we analyzed the influence of age, sex, body mass index (BMI), smoking, and education on salivary protein signatures in whole saliva samples of 187 individuals. Subjects were randomly selected from the population-based Study of Health in Pomerania (SHIP-Trend).

2017-05-16 | PXD006367 | Pride

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Temporary Labor Migration and Spouses' Marital Quality: Evidence from Nepal.

Project description:ObjectiveThis study investigated the effect of temporary labor migration on spouses' marital quality.BackgroundHow temporary international labor migration affects the marital relationship remains unclear. Research shows migration increases couples' risk of dissolution, whereas studies of spouses' marital quality-much of which is cross-sectional and/or limited to either internal or joint migration-is more mixed. This lack of consensus masks the possibility that, under certain conditions, migration may improve spouses' marital quality.MethodThis study uses data from the Chitwan Valley Family Study, a panel study set in Nepal, and primary data collected among a subsample of migrant husbands (in East Asia, Middle East) and their wives and nonmigrant couples (in Nepal).ResultsFindings from linear regression models show that, relative to non-migrant spouses, spouses engaged in temporary international labor migration report significantly higher marital quality-less conflict and more love-net of marital quality assessed 6 years earlier. However, these benefits are not enjoyed equally between spouses: husbands' marital quality improves, whereas changes in their wives' are less conclusive.ConclusionThe fact that these benefits (a) diverge from previous understandings and (b) vary by spouse's gender extends current understandings of the conditions shaping this association: social and structural forces supporting men as breadwinners, a strong husband-wife bond facilitating husbands' migration, and marriage-protective social environments at both ends of migration.

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Project description:The study aims to evaluate use of regorafenib in clinical practice in Hungary. The study should provide information about clinical characteristics of Hungarian regorafenib patients as well as information about safety and efficacy of regorafenib in Hungarian patients with metastatic colorectal cancer. This much needed data is required by the National Health Insurance Fund in order to accept regorafenib into the regular reimbursement system. This study is proposed to be based on patient data from the Hungarian National Health Insurance Fund’s Database. Data to be analyzed includes patient demography and baseline tumor characteristics, overall survival, time to treatment failure, duration of treatment, average dose and dose modifications, and adverse events. Further, treatment costs will be estimated.

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The Biological Embedding of Early Life Socioeconomic and Family Adversity in Children’s Genome-wide DNA Methylation

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2018-12-07 | GSE94734 | GEO

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