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Effectiveness of a design thinking-based health education program intervention for patients with temporary enterostomies: a randomized controlled trial

ABSTRACT: Interventions: Experimental group:Health education using the Health Education Program for Patients with Temporary Enterostomy developed in advance;Control group:General Health Education Primary outcome(s): Self-care capabilities of patients with stoma;Incidence of stoma-related complications Study Design: Parallel

DISEASE(S): Temporary Colostomy For Colorectal Cancer

PROVIDER: 87759 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Construction and application of an evidence-based temporary enterostomy health education

Project description:Interventions: Control Group:Provide routine health education during the period from temporary enterostomy surgery to stoma return surgery;Observation Group:On the basis of routine health education, apply the Skinner program teaching method to provide health education for patients. Primary outcome(s): Enterostomy patients self-management questionnaire;the Chinese Caregiver Preparedness Scale Study Design: Parallel

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Investigation of gene expression changes after mindfulness awareness program or health education program

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Evaluation of Quality of Life and Period of Hospitalization by Education

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Project description:The aim of this study is to determine the effect of stoma care training given at home via videoconferencing after discharge on the self-efficacy and compliance with stoma of individuals with stoma. In addition to the main purpose, it is aimed to determine whether stoma care education given via video conference at home has an effect on individuals with stoma to perform their own stoma care.

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Epidermal growth factor shedding directs macrophage education in cancer

Project description:Macrophages in the tumor microenvironment have a significant impact on tumor progression. Depending on the signaling environment in the tumor, macrophages can either support or constrain tumor growth and metastasis. It is therefore of therapeutic interest to identify the tumor-derived factors that control macrophage education. With this aim, we correlated the expression of ADAM proteases, which are key mediators of cell-cell signaling, to the expression of pro-tumorigenic macrophage markers in human cancer cohorts. We identified ADAM17, a sheddase upregulated in many cancer types, as a protein of interest. Depletion of ADAM17 in cancer cell lines reduced the expression of several pro-tumorigenic markers in neighboring macrophages in vitro as well as in mouse tumor models. Accordingly, ADAM17-/- educated macrophages demonstrated a reduced ability to induce cancer cell invasion. Using quantitative mass spectrometry-based proteomics, we identified HB-EGF, shed by ADAM17 in the cancer cells, as the implicated molecular mediator of macrophage education. Additionally, RNA-seq and ELISA experiments revealed that ADAM17-dependent HB-EGF release induces the expression and secretion of CXCL chemokines in macrophages, which in turn stimulates cancer cell invasion. In conclusion, we provide evidence that ADAM17 mediates a paracrine HB-EGF-chemokine feedback loop, whereby cancer cells hijack macrophages to promote tumor progression.

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