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A comparative study of the effects of Remimazolam Tosilate and Sevoflurane on perioperative oxidative stress response in patients undergoing radical surgery for colorectal cancer

ABSTRACT: Interventions: The sevoflurane group (S group) :The S group received inhalational anesthesia with sevoflurane for induction and maintenance.;Remazolam group (R group):Induction and maintenance of anesthesia using remidazolam Primary outcome(s): Catalase;Glutathione;Oxidized glutathione;Malondialdehyde;Superoxide dismutase Study Design: Parallel

DISEASE(S): Perioperative Oxidative Stress Response In Patients Undergoing Radical Surgery For Colorectal Cancer

PROVIDER: 89547 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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sevoflurane exposures on neonatal and adult mice,LC-MSMS

Project description:Sevoflurane is the most commonly used general anesthetic in pediatric surgery, but it has the potential to be neurotoxic. Previous research found that long-term or multiple sevoflurane exposures could cause cognitive deficits in newborn mice but not adult mice, whereas short-term or single inhalations had little effect on cognitive function at both ages. The mechanisms behind these effects, however, are unclear. In the current study, 6- and 60-day-old C57bl mice in the sevoflurane groups were given 3% sevoflurane plus 60% oxygen for three consecutive days, each lasting 2 hours, while those in the control group only got 60% oxygen. The cortex tissues were harvested on the 8th or 62nd day. The tandem mass tags (TMT)pro-based quantitative proteomics combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysi were applied to analyze the influences of multiple sevoflurane anesthesia on the cerebral cortex in mice with various ages. A total of 6247 proteins were measured using the combined quantitative proteomics methods of TMTpro-labeled and LC-MS/MS, 443 of which were associated to the age-dependent neurotoxic mechanism of repeated sevoflurane anesthesia. Our findings would help to further the mechanistic study of age-dependent anesthetic neurotoxicity and contribute to seek for effective protection in the developing brain under general anesthesia.

2022-12-08 | PXD037294 | Pride

Sevoflurane increases FKBP5 expression in microglia in the brains of aged marmosets and mice

Project description:Background: Inhalation anesthetics may trigger the hypothalamic–pituitary–adrenal (HPA) axis. FK-506 binding protein (FKBP5) is a critical factor that regulates the HPA axis and is associated with perioperative neurocognitive impairment. However, it is unclear how inhalation anesthetics affects the expression of FKBP5 in different neural cells in the brain. Methods: We used single-nucleus RNA sequencing to characterize hippocampal transcriptome profiles in the brains of aged marmosets and mice after sevoflurane anesthesia. Results: Higher levels of FKBP5 were found in the hippocampi of aged mice after sevoflurane anesthesia. Single nuclear RNA sequencing results from aged mice and marmosets showed that the increased expression of FKBP5 mainly occurred in microglia. The expression of FKBP5 in the hippocampi of aged marmosets and mice increased following long-term exposure to sevoflurane anesthesia. Additionally, the brains of these animals displayed a marked increase in the expression of FKBP5 in microglia after sevoflurane anesthesia. Conclusion: Long-term exposure to sevoflurane augments FKBP5 expression in the hippocampi of aged marmosets and mice, specifically in the microglia.

2024-10-30 | GSE234493 | GEO

Expression data from sevoflurane anesthesia treated rat

Project description:Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases. However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders (PNCD), especially in anesthesia related brain dysfunction, remains unknown. We explored the expression and regulation pattern profiles of lncRNAs in the hippocampus of aged rats after sevoflurane anesthesia with microarrays.

2020-12-29 | GSE139220 | GEO

Comparison of global gene expression profile associated with inhalation anesthesia between sevoflurane and desflurane

Project description:Comparative gene expression profiling analysis of RNA-seq data for livers from rats subjected to inhalational anesthesia with either sevoflurane or desflurane and their controls that were treated with sevoflurane or desflurane only briefly until the loss of their consciousness.

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Compare the effects of sevoflurane or propofol on perioperative glucose metabolism in patients undergoing laparoscopic colorectal cancer surgery

Project description:Interventions: Group S:induction 2-3% and maintenance 1.5-2.5% of sevoflurane during operation;Group S+L:induction 2-3% and 1.5-2.5%maintenance of sevoflurane during operation, lipid emulsions 1mg/kg/h during operations;Group P:induction and maintenance of propofol 3.0-4.0ug/ml during operation Primary outcome(s): asprosin;blood glucose;insulin Study Design: Parallel

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Expression data from sevoflurane anesthesia treated rat

Project description:Expression data from sevoflurane anesthesia treated rat

| PRJNA578770 | ENA

Project description:Although sevoflurane is one of the most commonly used inhalational anesthetic agent, the popularity of desflurane is increasing to a similar level. The main beneficial property of desflurane is the relatively fast emergence of the patient from the anesthetic state after halting its supply compared with anesthesia using other anesthetic agents. However, there has been no comprehensive comparison of the effects of these two anesthetic agents on alterations in liver gene expression profiles in animals, including humans, to assess the kinds of biological abnormalities/changes and their levels in the host. Thus, we compared alterations in the global gene expression profiles in the livers of rats subjected to inhalational anesthesia by sevoflurane or desflurane by a next-generation sequencing method.

2024-02-21 | GSE244436 | GEO

Gene expression of brain regions activated by sevoflurane and propofol

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2021-12-22 | GSE192399 | GEO

Protective effect of remote ischemic preconditioning combined with sevoflurane posttreatment on myocardial injury during laparoscopic radical resection of colorectal cancer

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