Genomics

Dataset Information

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EGAD00000000055

ABSTRACT: COLO-829 is a publicly available immortal cancer cell line and COLO-829BL is a lymphoblastoid cell line derived from the same patient

PROVIDER: EGAD00000000055 | EGA |

REPOSITORIES: EGA

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A comprehensive catalogue of somatic mutations from a human cancer genome.

Pleasance Erin D ED   Cheetham R Keira RK   Stephens Philip J PJ   McBride David J DJ   Humphray Sean J SJ   Greenman Chris D CD   Varela Ignacio I   Lin Meng-Lay ML   Ordóñez Gonzalo R GR   Bignell Graham R GR   Ye Kai K   Alipaz Julie J   Bauer Markus J MJ   Beare David D   Butler Adam A   Carter Richard J RJ   Chen Lina L   Cox Anthony J AJ   Edkins Sarah S   Kokko-Gonzales Paula I PI   Gormley Niall A NA   Grocock Russell J RJ   Haudenschild Christian D CD   Hims Matthew M MM   James Terena T   Jia Mingming M   Kingsbury Zoya Z   Leroy Catherine C   Marshall John J   Menzies Andrew A   Mudie Laura J LJ   Ning Zemin Z   Royce Tom T   Schulz-Trieglaff Ole B OB   Spiridou Anastassia A   Stebbings Lucy A LA   Szajkowski Lukasz L   Teague Jon J   Williamson David D   Chin Lynda L   Ross Mark T MT   Campbell Peter J PJ   Bentley David R DR   Futreal P Andrew PA   Stratton Michael R MR  

Nature 20091216 7278

All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth advantage and are implicated in cancer development, whereas the remainder are passengers. Here we have sequenced the genomes of a malignant melanoma and a lymphoblastoid cell line from the same person, providing the first comprehensive catalogue of somatic mutations from an individual cancer. The catalogue provides remarkable insights into the forces that have shaped this  ...[more]

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