Ontology highlight
ABSTRACT:
PROVIDER: EGAD00000000055 | EGA |
REPOSITORIES: EGA
Pleasance Erin D ED Cheetham R Keira RK Stephens Philip J PJ McBride David J DJ Humphray Sean J SJ Greenman Chris D CD Varela Ignacio I Lin Meng-Lay ML Ordóñez Gonzalo R GR Bignell Graham R GR Ye Kai K Alipaz Julie J Bauer Markus J MJ Beare David D Butler Adam A Carter Richard J RJ Chen Lina L Cox Anthony J AJ Edkins Sarah S Kokko-Gonzales Paula I PI Gormley Niall A NA Grocock Russell J RJ Haudenschild Christian D CD Hims Matthew M MM James Terena T Jia Mingming M Kingsbury Zoya Z Leroy Catherine C Marshall John J Menzies Andrew A Mudie Laura J LJ Ning Zemin Z Royce Tom T Schulz-Trieglaff Ole B OB Spiridou Anastassia A Stebbings Lucy A LA Szajkowski Lukasz L Teague Jon J Williamson David D Chin Lynda L Ross Mark T MT Campbell Peter J PJ Bentley David R DR Futreal P Andrew PA Stratton Michael R MR
Nature 20091216 7278
All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth advantage and are implicated in cancer development, whereas the remainder are passengers. Here we have sequenced the genomes of a malignant melanoma and a lymphoblastoid cell line from the same person, providing the first comprehensive catalogue of somatic mutations from an individual cancer. The catalogue provides remarkable insights into the forces that have shaped this ...[more]