Genomics

Dataset Information

0

EGAS00000000046-ega-20110530 - samples

ABSTRACT: ICGC Germany PedBrain Medulloblastoma Pilot_2_LM

PROVIDER: EGAD00001000027 | EGA |

REPOSITORIES: EGA

Json Xml
altmetric image

Publications

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.

Rausch Tobias T   Jones David T W DT   Zapatka Marc M   Stütz Adrian M AM   Zichner Thomas T   Weischenfeldt Joachim J   Jäger Natalie N   Remke Marc M   Shih David D   Northcott Paul A PA   Pfaff Elke E   Tica Jelena J   Wang Qi Q   Massimi Luca L   Witt Hendrik H   Bender Sebastian S   Pleier Sabrina S   Cin Huriye H   Hawkins Cynthia C   Beck Christian C   von Deimling Andreas A   Hans Volkmar V   Brors Benedikt B   Eils Roland R   Scheurlen Wolfram W   Blake Jonathon J   Benes Vladimir V   Kulozik Andreas E AE   Witt Olaf O   Martin Dianna D   Zhang Cindy C   Porat Rinnat R   Merino Diana M DM   Wasserman Jonathan J   Jabado Nada N   Fontebasso Adam A   Bullinger Lars L   Rücker Frank G FG   Döhner Konstanze K   Döhner Hartmut H   Koster Jan J   Molenaar Jan J JJ   Versteeg Rogier R   Kool Marcel M   Tabori Uri U   Malkin David D   Korshunov Andrey A   Taylor Michael D MD   Lichter Peter P   Pfister Stefan M SM   Korbel Jan O JO  

Cell 20120101 1-2

Genomic rearrangements are thought to occur progressively during tumor development. Recent findings, however, suggest an alternative mechanism, involving massive chromosome rearrangements in a one-step catastrophic event termed chromothripsis. We report the whole-genome sequencing-based analysis of a Sonic-Hedgehog medulloblastoma (SHH-MB) brain tumor from a patient with a germline TP53 mutation (Li-Fraumeni syndrome), uncovering massive, complex chromosome rearrangements. Integrating TP53 statu  ...[more]

Similar Datasets

Transcriptomics ICGC Pancreas: Genomewide DNA methylation patterns in pancreatic ductal adenocarcinoma (gene expression of 103 samples)
2014-05-05 | GSE50827 | GEO
Transcriptomics Single nucelus RNA sequencing of 14 week EGA fetal skin
2023-02-08 | GSE195657 | GEO
Methylation profiling Epigenetic methylation chip analysis of childhood medulloblastoma patient samples
2021-06-04 | GSE156012 | GEO
Genomics Effects of entero-gastro-anastomosis (EGA) surgery in ob/ob mice on pancreatic islet miRNA expression
2020-08-05 | GSE133569 | GEO
Transcriptomics Effects of entero-gastro-anastomosis (EGA) surgery in ob/ob mice on pancreatic islet gene expression
2020-08-05 | GSE133577 | GEO
Methylation profiling Methylation data from presentation and relapsed medulloblastoma tumour samples
2015-04-23 | GSE62618 | GEO
Genomics RNA-seq_DATA_SET_ICGC_PedBrainTumor_Medulloblastoma_Discovery_Cohort - samples
| EGAD00001000328 | EGA
Genomics Bisulfite-Seq_DATA_SET_pyro_MB_2013_07_10 - samples
| EGAD00001000644 | EGA
Genomics ena-DATASET-DKFZ-IBIOS-25-01-2016-08:42:37:641-84 - samples
| EGAD00001001891 | EGA
Genomics RNA-SEQ_DATA_SET_rain_PA_2012_10_22 - samples
| EGAD00001000617 | EGA