Genomics

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Ena-DATASET-Genentech-22-08-2012-07:05:26:504-11 - samples

ABSTRACT: RNA sequencing of SCLC tumor/normal sample pairs and cell lines

PROVIDER: EGAD00001000223 | EGA |

REPOSITORIES: EGA

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Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.

Rudin Charles M CM   Durinck Steffen S   Stawiski Eric W EW   Poirier John T JT   Modrusan Zora Z   Shames David S DS   Bergbower Emily A EA   Guan Yinghui Y   Shin James J   Guillory Joseph J   Rivers Celina Sanchez CS   Foo Catherine K CK   Bhatt Deepali D   Stinson Jeremy J   Gnad Florian F   Haverty Peter M PM   Gentleman Robert R   Chaudhuri Subhra S   Janakiraman Vasantharajan V   Jaiswal Bijay S BS   Parikh Chaitali C   Yuan Wenlin W   Zhang Zemin Z   Koeppen Hartmut H   Wu Thomas D TD   Stern Howard M HM   Yauch Robert L RL   Huffman Kenneth E KE   Paskulin Diego D DD   Illei Peter B PB   Varella-Garcia Marileila M   Gazdar Adi F AF   de Sauvage Frederic J FJ   Bourgon Richard R   Minna John D JD   Brock Malcolm V MV   Seshagiri Somasekar S  

Nature genetics 20120902 10

Small-cell lung cancer (SCLC) is an exceptionally aggressive disease with poor prognosis. Here, we obtained exome, transcriptome and copy-number alteration data from approximately 53 samples consisting of 36 primary human SCLC and normal tissue pairs and 17 matched SCLC and lymphoblastoid cell lines. We also obtained data for 4 primary tumors and 23 SCLC cell lines. We identified 22 significantly mutated genes in SCLC, including genes encoding kinases, G protein-coupled receptors and chromatin-m  ...[more]

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