Dataset Information
Ena-DATASET-UNIGE-AL-25-11-2014-10:47:01:523-1962 - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001083 | EGA |
REPOSITORIES: EGA
Publications
Biased allelic expression in human primary fibroblast single cells.
American journal of human genetics 20141231 1
The study of gene expression in mammalian single cells via genomic technologies now provides the possibility to investigate the patterns of allelic gene expression. We used single-cell RNA sequencing to detect the allele-specific mRNA level in 203 single human primary fibroblasts over 133,633 unique heterozygous single-nucleotide variants (hetSNVs). We observed that at the snapshot of analyses, each cell contained mostly transcripts from one allele from the majority of genes; indeed, 76.4% of th ...[more]
