Dataset Information
PCGP Germline WXS - samples
Ontology highlight
ABSTRACT:
PROVIDER: EGAD00001001433 | EGA |
REPOSITORIES: EGA
Publications
Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data.
Genome biology 20121211 12
<h4>Background</h4>Telomeres are the protective arrays of tandem TTAGGG sequence and associated proteins at the termini of chromosomes. Telomeres shorten at each cell division due to the end-replication problem and are maintained above a critical threshold in malignant cancer cells to prevent cellular senescence or apoptosis. With the recent advances in massive parallel sequencing, assessing telomere content in the context of other cancer genomic aberrations becomes an attractive possibility. We ...[more]
