Genomics

Dataset Information

0

Ena-DATASET-Hospital Clinic Barcelona-21-07-2015-12:09:53:274-78 - samples

ABSTRACT: RNASeq sequencing. Each library was sequenced using TruSeq SBS Kit v3-HS, in paired-end mode with a read length of 2 × 76 bp. We generated more than 20 million paired-end reads for each sample in a fraction of a sequencing lane on HiSeq2000 (Illumina Inc.) following the manufacturer’s protocol. Image analysis, base calling and quality scoring of the run were processed using the manufacturer’s software Real Time Analysis (RTA 1.13.48) and followed by generation of FASTQ sequence files.

PROVIDER: EGAD00001001443 | EGA |

REPOSITORIES: EGA

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Publications

Non-coding recurrent mutations in chronic lymphocytic leukaemia.

Puente Xose S XS   Beà Silvia S   Valdés-Mas Rafael R   Villamor Neus N   Gutiérrez-Abril Jesús J   Martín-Subero José I JI   Munar Marta M   Rubio-Pérez Carlota C   Jares Pedro P   Aymerich Marta M   Baumann Tycho T   Beekman Renée R   Belver Laura L   Carrio Anna A   Castellano Giancarlo G   Clot Guillem G   Colado Enrique E   Colomer Dolors D   Costa Dolors D   Delgado Julio J   Enjuanes Anna A   Estivill Xavier X   Ferrando Adolfo A AA   Gelpí Josep L JL   González Blanca B   González Santiago S   González Marcos M   Gut Marta M   Hernández-Rivas Jesús M JM   López-Guerra Mónica M   Martín-García David D   Navarro Alba A   Nicolás Pilar P   Orozco Modesto M   Payer Ángel R ÁR   Pinyol Magda M   Pisano David G DG   Puente Diana A DA   Queirós Ana C AC   Quesada Víctor V   Romeo-Casabona Carlos M CM   Royo Cristina C   Royo Romina R   Rozman María M   Russiñol Nuria N   Salaverría Itziar I   Stamatopoulos Kostas K   Stunnenberg Hendrik G HG   Tamborero David D   Terol María J MJ   Valencia Alfonso A   López-Bigas Nuria N   Torrents David D   Gut Ivo I   López-Guillermo Armando A   López-Otín Carlos C   Campo Elías E  

Nature 20150722 7574

Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of the genomic landscape of 452 CLL cases and 54 patients with monoclonal B-lymphocytosis, a precursor disorder. We extend the number of CLL driver alterations, including changes in ZNF292, ZMYM3, ARID1A and PTPN11. We also identify novel recurrent mutations in non-coding regions, including the  ...[more]

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