Genomics

Dataset Information

0

Ena-DATASET-Hospital Clinic Barcelona-13-08-2015-12:02:30:199-229 - samples

ABSTRACT: Whole Genome sequencing. 2 μg of genomic DNA from each sample was used for the construction of two short-insert paired-end sequencing libraries. Both types of libraries were sequenced in paired-end mode on Illumina GAIIx (2 × 151 bp) using Sequencing kit v4 or Illumina HiSeq2000 (2x101 bp) using TruSeq SBS Kit v3.

PROVIDER: EGAD00001001466 | EGA |

REPOSITORIES: EGA

Json Xml
altmetric image

Publications

Non-coding recurrent mutations in chronic lymphocytic leukaemia.

Puente Xose S XS   Beà Silvia S   Valdés-Mas Rafael R   Villamor Neus N   Gutiérrez-Abril Jesús J   Martín-Subero José I JI   Munar Marta M   Rubio-Pérez Carlota C   Jares Pedro P   Aymerich Marta M   Baumann Tycho T   Beekman Renée R   Belver Laura L   Carrio Anna A   Castellano Giancarlo G   Clot Guillem G   Colado Enrique E   Colomer Dolors D   Costa Dolors D   Delgado Julio J   Enjuanes Anna A   Estivill Xavier X   Ferrando Adolfo A AA   Gelpí Josep L JL   González Blanca B   González Santiago S   González Marcos M   Gut Marta M   Hernández-Rivas Jesús M JM   López-Guerra Mónica M   Martín-García David D   Navarro Alba A   Nicolás Pilar P   Orozco Modesto M   Payer Ángel R ÁR   Pinyol Magda M   Pisano David G DG   Puente Diana A DA   Queirós Ana C AC   Quesada Víctor V   Romeo-Casabona Carlos M CM   Royo Cristina C   Royo Romina R   Rozman María M   Russiñol Nuria N   Salaverría Itziar I   Stamatopoulos Kostas K   Stunnenberg Hendrik G HG   Tamborero David D   Terol María J MJ   Valencia Alfonso A   López-Bigas Nuria N   Torrents David D   Gut Ivo I   López-Guillermo Armando A   López-Otín Carlos C   Campo Elías E  

Nature 20150722 7574

Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of the genomic landscape of 452 CLL cases and 54 patients with monoclonal B-lymphocytosis, a precursor disorder. We extend the number of CLL driver alterations, including changes in ZNF292, ZMYM3, ARID1A and PTPN11. We also identify novel recurrent mutations in non-coding regions, including the  ...[more]

Similar Datasets

Genomics ena-DATASET-Hospital Clinic Barcelona-21-07-2015-12:09:53:274-78 - samples
| EGAD00001001443 | EGA
Genomics ena-DATASET-ICR-GSR-03-10-2014-09:33:38:920-870 - samples
| EGAD00001001021 | EGA
Genomics ena-DATASET-ICR-GSR-06-08-2015-17:20:28:712-26 - samples
| EGAD00001001462 | EGA
Genomics ChIP-seq profiling of H3K27 tri-methylation in Ezh2-deficient and control murine lung epithelium at day E16.5
2015-05-11 | GSE57392 | GEO
Transcriptomics RNA-seq profiling of gene expression in Ezh2-deficient and control murine lung epithelial and stromal cell populations at day E16.5
2015-05-11 | GSE57391 | GEO
Transcriptomics Genome-wide binding and mechanistic analyses of Smchd1 mediated epigenetic regulation [RNA-Seq]
2015-06-11 | GSE65747 | GEO
Transcriptomics Transcriptome profiling for genes transcriptionally regulated by Smchd1 in lymphoma cell lines.
2015-03-13 | GSE64099 | GEO
Transcriptomics Analysis of Transcriptome in small intestine after radiation injury with treatment of pravastatin
2021-08-29 | GSE182829 | GEO
Genomics ChIP-seq profiling of H3K27 tri-methylation in Ezh2-deficient and control murine lung epithelium at day E16.5
2015-05-11 | E-GEOD-57392 | biostudies-arrayexpress
Transcriptomics Transcriptome profiling of purified mouse platelets
2016-04-16 | GSE75896 | GEO