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EGAS00001000482-sc-20170419 - samples

ABSTRACT: Integrated callset of high coverage Egyptian genomes from the Pagani et al. 2015 AJHG paper (doi: http://dx.doi.org/10.1016/j.ajhg.2015.04.019)

PROVIDER: EGAD00001003295 | EGA |

REPOSITORIES: EGA

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Tracing the route of modern humans out of Africa by using 225 human genome sequences from Ethiopians and Egyptians.

Pagani Luca L Schiffels Stephan S Gurdasani Deepti D Danecek Petr P Scally Aylwyn A Chen Yuan Y Xue Yali Y Haber Marc M Ekong Rosemary R Oljira Tamiru T Mekonnen Ephrem E Luiselli Donata D Bradman Neil N Bekele Endashaw E Zalloua Pierre P Durbin Richard R Kivisild Toomas T Tyler-Smith Chris C

American journal of human genetics 20150528 6

The predominantly African origin of all modern human populations is well established, but the route taken out of Africa is still unclear. Two alternative routes, via Egypt and Sinai or across the Bab el Mandeb strait into Arabia, have traditionally been proposed as feasible gateways in light of geographic, paleoclimatic, archaeological, and genetic evidence. Distinguishing among these alternatives has been difficult. We generated 225 whole-genome sequences (225 at 8× depth, of which 8 were incre ...[more]

PMID: 26027499

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