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Ena-DATASET-KNIH-31-07-2017-05:30:39:110-1201 - samples

ABSTRACT: A IPS06_X_ENeuron_WGBS paired end data for Early neuron cells(Tuj1)

PROVIDER: EGAD00001003478 | EGA |

REPOSITORIES: EGA

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ena-DATASET-KNIH-31-07-2017-05:27:41:077-1198 - samples

Project description:A IPS03_N_ENeuron_WGBS paired end data for Early neuron cells(Tuj1)

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ena-DATASET-KNIH-31-07-2017-05:44:51:109-1216 - samples

Project description:A IPS06_X_ENeuron_mRNA-Seq paired end data for Early neuron cells(Tuj1)

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ena-DATASET-KNIH-31-07-2017-05:51:35:643-1226 - samples

Project description:A IPS03_N_ENeuron_smRNA-Seq single end data for Early neuron cells(Tuj1)

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ena-DATASET-KNIH-31-07-2017-05:43:02:965-1213 - samples

Project description:A IPS03_N_ENeuron_mRNA-Seq paired end data for Early neuron cells(Tuj1)

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ena-DATASET-KNIH-31-07-2017-05:53:33:575-1230 - samples

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Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans.

Project description:Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic basis of susceptibility to BP, we performed the first genome-wide association study (GWAS) in Germans. This GWAS was combined with HLA locus targeted sequencing in an additional independent BP cohort. The strongest association with BP in Germans tested in this study was observed in the two HLA loci, HLA-DQA1*05:05 and HLA-DRB1*07:01. Further studies with increased sample sizes and complex studies integrating multiple pathogenic drivers will be conducted.

| S-EPMC8136166 | biostudies-literature

Differentially regulted genes in neural stem cells treated by oleanolic acid

Project description:Oleanolic acid significantly inhibited neurosphere formation in a dose-dependent manner, and achieved a maximum effect at 10 nM. OA also reduced the 5-ethynyl-2’-deoxyuridine (EdU) incorporation into NSCs, indicating an inhibition on proliferation of NSCs. Next, in western blotting analysis, the protein expression of neuron-specific marker tubulin-βⅢ (TuJ1) and Mash1 was increased, while the astrocyte-specific marker glial fibrillary acidic protein (GFAP) decreased. In immunofluorescence analysis, OA significantly elevated the percentage of TuJ1-positive cells and reduced GFAP-positive cells. Using DNA microarrays, 183 genes were found to be differentially regulated by OA.

2012-06-02 | GSE38394 | GEO

Differentially regulted genes in neural stem cells treated by oleanolic acid

Project description:Oleanolic acid significantly inhibited neurosphere formation in a dose-dependent manner, and achieved a maximum effect at 10 nM. OA also reduced the 5-ethynyl-2M-bM-^@M-^Y-deoxyuridine (EdU) incorporation into NSCs, indicating an inhibition on proliferation of NSCs. Next, in western blotting analysis, the protein expression of neuron-specific marker tubulin-M-NM-2M-bM-^EM-" (TuJ1) and Mash1 was increased, while the astrocyte-specific marker glial fibrillary acidic protein (GFAP) decreased. In immunofluorescence analysis, OA significantly elevated the percentage of TuJ1-positive cells and reduced GFAP-positive cells. Using DNA microarrays, 183 genes were found to be differentially regulated by OA. Neural stem cells derived form mouse embrynic brains were treated with Oleanolic acid or not. Each group had 4 biological relicates each from a mouse.

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