Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Leukocyte, Cell Culture
SUBMITTER: Jesse Mobbs
LAB HEAD: Anthony W Purcell
PROVIDER: PXD006455 | Pride | 2017-07-03
REPOSITORIES: Pride
Action | DRS | |||
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C501.xml | Xml | |||
C702.xml | Xml | |||
P120161215_jmobbs_C501_1_12.mgf | Mgf | |||
P120161215_jmobbs_C501_1_12.raw | Raw | |||
P120161215_jmobbs_C501_1_13.mgf | Mgf |
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Nature communications 20170626
Expression of HLA-C varies widely across individuals in an allele-specific manner. This variation in expression can influence efficacy of the immune response, as shown for infectious and autoimmune diseases. MicroRNA binding partially influences differential HLA-C expression, but the additional contributing factors have remained undetermined. Here we use functional and structural analyses to demonstrate that HLA-C expression is modulated not just at the RNA level, but also at the protein level. ...[more]