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T2D - samples

ABSTRACT: WTCCC2 samples from Type 2 Diabetes Cohort

PROVIDER: EGAD00010000232 | EGA |

REPOSITORIES: EGA

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The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.

Voight Benjamin F BF Kang Hyun Min HM Ding Jun J Palmer Cameron D CD Sidore Carlo C Chines Peter S PS Burtt Noël P NP Fuchsberger Christian C Li Yanming Y Erdmann Jeanette J Frayling Timothy M TM Heid Iris M IM Jackson Anne U AU Johnson Toby T Kilpeläinen Tuomas O TO Lindgren Cecilia M CM Morris Andrew P AP Prokopenko Inga I Randall Joshua C JC Saxena Richa R Soranzo Nicole N Speliotes Elizabeth K EK Teslovich Tanya M TM Wheeler Eleanor E Maguire Jared J Parkin Melissa M Potter Simon S Rayner N William NW Robertson Neil N Stirrups Kathleen K Winckler Wendy W Sanna Serena S Mulas Antonella A Nagaraja Ramaiah R Cucca Francesco F Barroso Inês I Deloukas Panos P Loos Ruth J F RJ Kathiresan Sekar S Munroe Patricia B PB Newton-Cheh Christopher C Pfeufer Arne A Samani Nilesh J NJ Schunkert Heribert H Hirschhorn Joel N JN Altshuler David D McCarthy Mark I MI Abecasis Gonçalo R GR Boehnke Michael M

PLoS genetics 20120802 8

Genome-wide association studies have identified hundreds of loci for type 2 diabetes, coronary artery disease and myocardial infarction, as well as for related traits such as body mass index, glucose and insulin levels, lipid levels, and blood pressure. These studies also have pointed to thousands of loci with promising but not yet compelling association evidence. To establish association at additional loci and to characterize the genome-wide significant loci by fine-mapping, we designed the "Me ...[more]

PMID: 22876189

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Project description:Cases with Type 1 Diabetes (T1D) in the UK, were part of the Wellcome Trust Case Control Consortium (WTCCC) - <a href="http://www.wtccc.org.uk" target="_blank">http://www.wtccc.org.uk</a> - that first reported in 2007: Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447, 661-678. [PubMed: <a href="http://www.ncbi.nlm.nih.gov/pubmed/17554300" target="_blank">17554300</a>] In this genome-wide association study (GWAS), funded by the NIH and JDRF, and sponsored by the Type 1 Diabetes Genetics Consortium (T1DGC), we were able to extend the case and control groups used in the WTCCC, with the intention of performing a well-powered meta-analysis. The study is written up as: Barrett, J.C., Clayton, D.G., Concannon, P., Akolkar, B., Cooper, J.D., Erlich, H.A., Julier, C., Morahan, G., Nerup, J., Nierras, C., Plagnol, V., Pociot, F., Schuilenburg, H., Smyth, D.J., Stevens, H., Todd, J.A., Walker, N.M., Rich, S.S. and The Type 1 Diabetes Genetics Consortium Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genetics, PMID: <a href="http://www.ncbi.nlm.nih.gov/pubmed/19430480" target="_blank">19430480</a>. Resources - data: * Case data from this study is deposited here (i.e. in dbGaP) * Control data from this experiment - with subjects from the 1958 British Birth Cohort - is deposited with the European Genotype Archive (EGA): <a href="http://www.ebi.ac.uk/ega/" target="_blank">http://www.ebi.ac.uk/ega/</a> from where the WTCCC data is also available. * A complete description of how to request all components of the meta-analysis is available at: <a href="http://www.t1dbase.org/page/PosterView/display/poster_id/324" target="_blank">http://www.t1dbase.org/page/PosterView/display/poster_id/324</a> * Additional genetic data on the same case subjects, including some HLA types, are available from the Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory (JDRF/WT-DIL): <a href="http://www-gene.cimr.cam.ac.uk/todd/" target="_blank">http://www-gene.cimr.cam.ac.uk/todd/</a> Resources - samples: Case and control DNA samples are also available: * Case DNA samples are available from the JDRF/WT-DIL, as above, and will be available from the NIDDK Genetics Repository at Rutgers: <a href="https://www.niddkrepository.org" target="_blank">https://www.niddkrepository.org</a> * Control DNA samples are available from the 1958 British Birth Cohort (aka National Child Development Study): <a href="http://www.cls.ioe.ac.uk/studies.asp?section=000100020003" target="_blank">http://www.cls.ioe.ac.uk/studies.asp?section=000100020003</a> Use restrictions: There are access limitations to both data and samples, in order to keep their use in line with subjects' consent.

Dataset Information

T2D - samples

Publications

The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.

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