Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000106 | EGA |
REPOSITORIES: EGA
Ramasamy Adaikalavan A Trabzuni Daniah D Guelfi Sebastian S Varghese Vibin V Smith Colin C Walker Robert R De Tisham T Coin Lachlan L de Silva Rohan R Cookson Mark R MR Singleton Andrew B AB Hardy John J Ryten Mina M Weale Michael E ME
Nature neuroscience 20140831 10
Germ-line genetic control of gene expression occurs via expression quantitative trait loci (eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions. We found that cis-eQTL signals (within 1 Mb of their target gene) were numerous, and many acted heterogeneously among regions and exons. Co-regulation analysis of shared eQTL signals produced well-defined modules of region-specific co-regulated genes, in contrast to standard coexpression analysis of the same samples. ...[more]