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Omics score: 1002

University College London

ABSTRACT: Organisation EGAO00000000420

PROVIDER: EGAO00000000420 | EGA |

REPOSITORIES: EGA

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Genetic variability in the regulation of gene expression in ten regions of the human brain.

Ramasamy Adaikalavan A Trabzuni Daniah D Guelfi Sebastian S Varghese Vibin V Smith Colin C Walker Robert R De Tisham T Coin Lachlan L de Silva Rohan R Cookson Mark R MR Singleton Andrew B AB Hardy John J Ryten Mina M Weale Michael E ME

Nature neuroscience 20140831 10

Germ-line genetic control of gene expression occurs via expression quantitative trait loci (eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions. We found that cis-eQTL signals (within 1 Mb of their target gene) were numerous, and many acted heterogeneously among regions and exons. Co-regulation analysis of shared eQTL signals produced well-defined modules of region-specific co-regulated genes, in contrast to standard coexpression analysis of the same samples. ...[more]

PMID: 25174004

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