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Dataset Information

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Duke-NUS Medical School Singapore

ABSTRACT: Organisation EGAO00000000709

PROVIDER: EGAO00000000709 | EGA |

REPOSITORIES: EGA

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Publications

Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma.

Jusakul Apinya A   Cutcutache Ioana I   Yong Chern Han CH   Lim Jing Quan JQ   Huang Mi Ni MN   Padmanabhan Nisha N   Nellore Vishwa V   Kongpetch Sarinya S   Ng Alvin Wei Tian AWT   Ng Ley Moy LM   Choo Su Pin SP   Myint Swe Swe SS   Thanan Raynoo R   Nagarajan Sanjanaa S   Lim Weng Khong WK   Ng Cedric Chuan Young CCY   Boot Arnoud A   Liu Mo M   Ong Choon Kiat CK   Rajasegaran Vikneswari V   Lie Stefanus S   Lim Alvin Soon Tiong AST   Lim Tse Hui TH   Tan Jing J   Loh Jia Liang JL   McPherson John R JR   Khuntikeo Narong N   Bhudhisawasdi Vajaraphongsa V   Yongvanit Puangrat P   Wongkham Sopit S   Totoki Yasushi Y   Nakamura Hiromi H   Arai Yasuhito Y   Yamasaki Satoshi S   Chow Pierce Kah-Hoe PK   Chung Alexander Yaw Fui AYF   Ooi London Lucien Peng Jin LLPJ   Lim Kiat Hon KH   Dima Simona S   Duda Dan G DG   Popescu Irinel I   Broet Philippe P   Hsieh Sen-Yung SY   Yu Ming-Chin MC   Scarpa Aldo A   Lai Jiaming J   Luo Di-Xian DX   Carvalho André Lopes AL   Vettore André Luiz AL   Rhee Hyungjin H   Park Young Nyun YN   Alexandrov Ludmil B LB   Gordân Raluca R   Rozen Steven G SG   Shibata Tatsuhiro T   Pairojkul Chawalit C   Teh Bin Tean BT   Tan Patrick P  

Cancer discovery 20170630 10

Cholangiocarcinoma (CCA) is a hepatobiliary malignancy exhibiting high incidence in countries with endemic liver-fluke infection. We analyzed 489 CCAs from 10 countries, combining whole-genome (71 cases), targeted/exome, copy-number, gene expression, and DNA methylation information. Integrative clustering defined 4 CCA clusters-fluke-positive CCAs (clusters 1/2) are enriched in <i>ERBB2</i> amplifications and <i>TP53</i> mutations; conversely, fluke-negative CCAs (clusters 3/4) exhibit high copy  ...[more]

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