Dataset Information
Queensland Centre for Medical Genomics, University of Queensland
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000249 | EGA |
REPOSITORIES: EGA
Publications
Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.
Nature communications 20141029
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic driving events have been underrepresented. Here we use a combination of whole-genome sequencing (WGS) and single-nucleotide polymorphism-array profiling to show that genomic catastrophes are frequent in EAC ...[more]
