Dataset Information
St. Anna Kinderspital, Medical University Vienna, Vienna, Austria
Ontology highlight
ABSTRACT:
PROVIDER: EGAO00000000820 | EGA |
REPOSITORIES: EGA
Publications
KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia.
Leukemia 20150428 8
High hyperdiploidy defines the largest genetic entity of childhood acute lymphoblastic leukemia (ALL). Despite its relatively low recurrence risk, this subgroup generates a high proportion of relapses. The cause and origin of these relapses remains obscure. We therefore explored the mutational landscape in high hyperdiploid (HD) ALL with whole-exome (n=19) and subsequent targeted deep sequencing of 60 genes in 100 relapsing and 51 non-relapsing cases. We identified multiple clones at diagnosis t ...[more]
