Genomics

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Genetic landscape of pediatric Rhabdomyosarcoma

ABSTRACT: We performed whole-genome sequencing of 13 paired tumor/normal Rhabdomyosarcoma genomes and analyzed somatically acquired single nucleotide variations SNVs, insertion/deletions, structural variations and copy number variations in the cancer genomes

PROVIDER: EGAS00001000256 | EGA |

REPOSITORIES: EGA

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<h4>Background</h4>Telomeres are the protective arrays of tandem TTAGGG sequence and associated proteins at the termini of chromosomes. Telomeres shorten at each cell division due to the end-replication problem and are maintained above a critical threshold in malignant cancer cells to prevent cellular senescence or apoptosis. With the recent advances in massive parallel sequencing, assessing telomere content in the context of other cancer genomic aberrations becomes an attractive possibility. We  ...[more]

PMID: 23232254

Publication: 1/2

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