Genomics

Dataset Information

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Genetic landscape of pediatric Osteosarcoma


ABSTRACT: We performed whole-genome sequencing of 37 paired tumor/normal OS genomes and analyzed somatically acquired single nucleotide variations (SNVs), insertion/deletions, structural variations and copy number variations in the cancer genomes

PROVIDER: EGAS00001000263 | EGA |

REPOSITORIES: EGA

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Publications

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.

Walia Mannu K MK   Ho Patricia Mw PM   Taylor Scott S   Ng Alvin Jm AJ   Gupte Ankita A   Chalk Alistair M AM   Zannettino Andrew Cw AC   Martin T John TJ   Walkley Carl R CR  

eLife 20160412


Mutations in the P53 pathway are a hallmark of human cancer. The identification of pathways upon which p53-deficient cells depend could reveal therapeutic targets that may spare normal cells with intact p53. In contrast to P53 point mutations in other cancer, complete loss of P53 is a frequent event in osteosarcoma (OS), the most common cancer of bone. The consequences of p53 loss for osteoblastic cells and OS development are poorly understood. Here we use murine OS models to demonstrate that el  ...[more]

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