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Whole Exome Sequencing of 15 Tumor/Normal pairs of inflammatory hepatocellular adenomas

ABSTRACT: The French ICGC project on liver tumors is coordinated by Pr Jessica Zucman-Rossi and funded by Inca (French Institute for Cancer). The aim of the present project is to identify the catalog of somatic and germline mutations in liver tumors. The present series corresponds to 15 Tumor/Normal pairs of Whole Exome Sequencing (WES) of IHCA samples. Aligned bam files can be both in hg19 (CHC750T/CHC750N; CHC2189T/CHC2189N; CHC2615T/CHC2614N) or hg38 (other samples).

PROVIDER: EGAS00001003686 | EGA |

REPOSITORIES: EGA

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Recurrent chromosomal rearrangements of <i>ROS1</i>, <i>FRK</i> and <i>IL6</i> activating JAK/STAT pathway in inflammatory hepatocellular adenomas.

Bayard Quentin Q Caruso Stefano S Couchy Gabrielle G Rebouissou Sandra S Bioulac Sage Paulette P Balabaud Charles C Paradis Valerie V Sturm Nathalie N de Muret Anne A Guettier Catherine C Bonsang Benjamin B Copie Christiane C Letouzé Eric E Calderaro Julien J Imbeaud Sandrine S Nault Jean-Charles JC Zucman-Rossi Jessica J

Gut 20200106 9

<h4>Background</h4>Inflammatory hepatocellular adenomas (IHCAs) are benign liver tumours characterised by an activation of the janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway caused by oncogenic activating mutations. However, a subset of IHCA lacks of identified mutation explaining the inflammatory phenotype.<h4>Methods</h4>657 hepatocellular adenomas developed in 504 patients were analysed for gene expression of 17 genes and for mutations in seven genes by s ...[more]

PMID: 31907296

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