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RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity

ABSTRACT: The spread of SARS-CoV-2 has fuelled the COVID-19 pandemic with its enduring medical and socioeconomic challenges due to subsequent waves and long-term consequences of great concern. Here we chart the molecular basis of COVID-19 pathogenesis, by analysing patientsÃ¢Â€Â™ immune response at single-cell resolution across disease course and severity. This approach confirms cell subpopulation-specific dysregulation in COVID-19 across disease course and severity and identifies a severity-associated activation of the receptor for advanced glycation endproduct (RAGE) pathway in monocytes.

PROVIDER: EGAS00001007529 | EGA |

REPOSITORIES: EGA

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TRB sequences targeting ORF1ab are associated with disease severity in hospitalized COVID-19 patients

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