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Expression profiling of peripheral blood mononuclear cells in normal controls and patients with Parkinson's disease

ABSTRACT: Autophagy is a highly conserved degradation pathway whereby not only cytosolic components but also aberrant proteins are sequestered within double-membraned vesicles. Parkinson's disease (PD) is pathologically characterized by accumulation of phosphorylated α-synuclein in the neuronal cytoplasm and its accumulation occurs in the peripheral autonomic nervous system as well as the central nervous system. In the brains of patients with PD, abnormal autophagy is known to occur and be involved with neurodegeneration. To investigate abnormal autophagy in peripheral blood mononuclear cells (PBMC) in the patients with PD, we performed whole transcriptome analysis of PBMC obtained from 9 normal controls and 10 patients with PD.

ORGANISM(S): Homo sapiens

PROVIDER: GSE100054 | GEO | 2017/07/27

SECONDARY ACCESSION(S): PRJNA390560

REPOSITORIES: GEO

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| phs001595 | dbGaP

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