Transcriptomics

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A compendium of antibiotic-induced transcription profiles reveals broad regulation of P. multocida virulence genes


ABSTRACT: Treatment of bacteria with antibiotics at or close to the inhibitory concentration leads to specific transcriptional responses often affecting target genes and targets pathways. A dataset of transcriptional profiles (compendium) induced by antibiotics with known mode-of-action (MoA) can be used to gain information on the putative MoA of novel substances with unknown MoAs. We used a Pasteurella multocida microarray to generate a compendium of transcriptional profiles and to obtain information on the putative MoA of a novel antibiotic compound. We also show a strong impact of the bacteriostatic antibiotics on P. multocida virulence gene transcription. Keywords: antibiotica treatment, time course

ORGANISM(S): Pasteurella multocida Pasteurella multocida subsp. multocida str. Pm70

PROVIDER: GSE10051 | GEO | 2008/06/01

SECONDARY ACCESSION(S): PRJNA108625

REPOSITORIES: GEO

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