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Gene expression analysis of SMARTA in response to LCMV or Lm-gp61 infection

ABSTRACT: Following infection with LCMV, CD4+ SMARTA TCR transgenic cells (specific for the gp61-80 epitope of the LCMV glycoprotein) rapidly expand, become effector cells, and go on to form a long-lived memory population. Following infection with a recombinant Listeria monocytogenes expressing the LCMV epitope gp61-80, SMARTA cells also expand but display defective effector differentiation and fail to form memory. In an attempt to understand the signals required for CD4 T cell memory differentiation, we compared gene expression by SMARTA cells at the peak of the primary response following either Lm-gp61 or LCMV infection. Keywords: response to LCMV or Lm-gp61 infection

ORGANISM(S): Mus musculus

PROVIDER: GSE10094 | GEO | 2008/01/11

SECONDARY ACCESSION(S): PRJNA108663

REPOSITORIES: GEO

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