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SUMOylation Regulates miR-34b/c Targeted Gene Expression Program [miRNA-seq]

ABSTRACT: The microRNAs known as miR-34 family suppress the expression of a suit of proteins involved in oncogenesis and pluripotency, including c-Myc. Their expression is frequently down regulated in cancers; however the regulation of their expression is not well understood. Through genome-wide miRNA profiling and mechanistic analysis, we identified an important role of SUMOylation in miR-34b/c expression, regulating the expression of c-Myc and all other tested miR-34 targets.

ORGANISM(S): Homo sapiens

PROVIDER: GSE101179 | GEO | 2017/07/12

SECONDARY ACCESSION(S): PRJNA393915

REPOSITORIES: GEO

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SUMOylation Regulates miR-34b/c Targeted Gene Expression Program [RNA-seq]

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