Transcriptomics

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Transcriptome comparison of NKp80+ and NKp80- CD8+ CCR7- TCR alpha beta + T cells


ABSTRACT: We have performed whole genome expression arrays covering over 47000 transcripts comparing the transcriptional profile of NKp80+ to NKp80- CD8+ CCR7- alpha beta T cells. A highly similar global gene expression profile was observed between both memory phenotype T cell subsets. Interestingly, the majority of differentially expressed genes are immune-associated. NKp80+ cells contained markedly increased levels of transcripts encoding for MHC class I and II molecules and for numerous members of the KIR family. Also other NK-related transcripts were more abundantly expressed in the NKp80+ subset. With regards to cytokines, chemokines and their receptors, transcripts important for homeostasis and proliferation are expressed differently. Also transcripts encoding for adhesion molecules are present at different levels in both T cell subsets. Further cytotoxic effector molecules are expressed differently. Keywords: cell type comparsion

ORGANISM(S): Homo sapiens

PROVIDER: GSE10178 | GEO | 2008/11/12

SECONDARY ACCESSION(S): PRJNA108387

REPOSITORIES: GEO

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