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Single-cell transcriptomic analysis of blood T cells from healthy controls, MS patients and COVID-19 patients by 10X genomics

ABSTRACT: In order to better understand the functional properties of this type of cells under different circumstances, we integrated the single-cell RNA-seq data of peripheral blood CD8+ T cells from healthy subjects, MS patients and COVID-19 patients generated from the 10X Genomics platform using the Seurat package. KIR+CD8+ T cells from different conditions (healthy, MS, and COVID-19) formed a distinct cluster with high expression of effector genes (GZMB and PRF1) as well as KIR transcripts. These findings reveal the commonality of KIR+CD8+ T cells across physiological and diseased status as well as their uniqueness relative to other CD8+ T cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE193770 | GEO | 2022/03/08

REPOSITORIES: GEO

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