Gene expression patterns define the hepatocyte-like cells derived by different strategies [RNA-seq]
Ontology highlight
ABSTRACT: We performed genome-wide gene profiling in hiPSC-Hep and hiHep and compared gene expression patterns in these two types of hepatocyte-like cells.Genes involving in fat digestion and absorption and metabolism enzymes were induced in both hiHeps and hiPSC-Heps. There were also hepatic genes not expressed in either hiPSC-Heps or hiHeps, including cytochrome P450-based metabolism genes and coagulation complements. Interestingly, when genes were clustered based on their hepatic functions, we found that for each hepatic function there were always a few genes not fully induced in either hiPSC-Heps or hiHeps.
ORGANISM(S): Homo sapiens
PROVIDER: GSE103075 | GEO | 2017/11/23
SECONDARY ACCESSION(S): PRJNA400277
REPOSITORIES: GEO
ACCESS DATA