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Gene expression patterns define the hepatocyte-like cells derived by different strategies [RNA-seq]

ABSTRACT: We performed genome-wide gene profiling in hiPSC-Hep and hiHep and compared gene expression patterns in these two types of hepatocyte-like cells.Genes involving in fat digestion and absorption and metabolism enzymes were induced in both hiHeps and hiPSC-Heps. There were also hepatic genes not expressed in either hiPSC-Heps or hiHeps, including cytochrome P450-based metabolism genes and coagulation complements. Interestingly, when genes were clustered based on their hepatic functions, we found that for each hepatic function there were always a few genes not fully induced in either hiPSC-Heps or hiHeps.

ORGANISM(S): Homo sapiens

PROVIDER: GSE103075 | GEO | 2017/11/23

SECONDARY ACCESSION(S): PRJNA400277

REPOSITORIES: GEO

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