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Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE106304 | GEO | 2017/10/30

SECONDARY ACCESSION(S): PRJNA416251

REPOSITORIES: GEO

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Syndecan-1 Controls Lung Tumorigenesis by Regulating miRNAs Packaged in Exosomes.

Project description:Syndecan-1 is a transmembrane proteoglycan expressed prominently by lung epithelium and has pleiotropic functions such as regulating cell migration, proliferation, and survival. Loss of syndecan-1 expression by lung cancer cells is associated with higher-grade cancers and worse clinical prognosis. We evaluated the effects of syndecan-1 in various cell-based and animal models of lung cancer and found that lung tumorigenesis was moderated by syndecan-1. We also demonstrate that syndecan-1 (or lack thereof) alters the miRNA cargo carried within exosomes exported from lung cancer cells. Analysis of the changes in miRNA expression identified a distinct shift toward augmented procancer signaling consistent with the changes found in lung adenocarcinoma. Collectively, our work identifies syndecan-1 as an important factor in lung cancer cells that shapes the tumor microenvironment through alterations in miRNA packaging within exosomes.

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Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [A549]

Project description:We evaluated the effect of syndecan-1 in various cell-based and animal models of lung cancer and found that lung tumorigenesis was promoted when cells lose syndecan-1 expression. We also demonstrate that syndecan-1 (or lack thereof) alters the microRNA (miRNA) cargo carried within exosomes exported from lung cancer cells. Analysis of the changes in miRNA expression identifies a distinct shift toward augmented pro-cancerous signaling, which are consistent with the changes found in lung adenocarcinoma. In all, our work identifies syndecan-1 as an important factor on lung cancer cells that control its ability to shape the lung tumor microenvironment through alterations in miRNA packaging within exosomes.

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Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [EKVX]

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Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes

Project description:Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes

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Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [EKVX]

Project description:Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [EKVX]

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Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [A549]

Project description:Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes [A549]

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Project description:This SuperSeries is composed of the SubSeries listed below.

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