Transcriptomics

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Microarray analysis of gene expression profiles with or without manipulations of neuronal activity


ABSTRACT: The process of synapse turnover is regulated by specific signaling mechanisms. Various molecules that promote formation and differentiation of synapses have been identified. Some of these molecules were classified as “synapse organizers,” as they were shown to initiate differentiation of hemi-synapses when they were expressed in non-neuronal cells and co-cultured with neurons.On the other hand, little is known about the mechanisms underlying destabilization and elimination of unnecessary synapses. We used microarray profiling of dissociated hippocampal culture to identify genes in response to the down-regulation of neuronal activity in hippocampal neurons.

ORGANISM(S): Mus musculus

PROVIDER: GSE107317 | GEO | 2018/01/16

SECONDARY ACCESSION(S): PRJNA419753

REPOSITORIES: GEO

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