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Gene expression in the colon from IL10 KO mice

ABSTRACT: That commensal bacteria can influence intestinal inflammation has been observed using other models of chronic colitis. Loss of IL-10, a major immunosuppressive cytokine, induces spontaneous colitis in mice. The incidence of spontaneous polyp formation in IL-10-deficient mice was also completely eliminated in the absence of STING We used microarrays to evaluate the inflammatory cytokine expression in the colon from IL10 KO mice and IL10/STING KO mice.

OTHER RELATED OMICS DATASETS IN: PRJNA421451PRJNA421452PRJNA421445

ORGANISM(S): Mus musculus

PROVIDER: GSE107810 | GEO | 2018/02/01

REPOSITORIES: GEO

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IL-27 driven transcriptional network identifies regulators of IL-10 expression across T helper cell subsets [IL10+ vs IL10-T helper cell RNA-seq]

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