Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14

ABSTRACT: The purpose of this study was to assess transcriptome changes in primary human airway epithelial cells following stimulation with RIG-I ligand.

ORGANISM(S): Homo sapiens

PROVIDER: GSE107898 | GEO | 2018/01/02

SECONDARY ACCESSION(S): PRJNA421899

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

Project description:The purpose of this study was to assess transcriptome changes in primary human airway epithelial cells following stimulation with RIG-I ligand.

2018-08-17 | GSE107897 | GEO

Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14

Project description:Differential RNASeq of human nasal epithelial cells stimulated with RIG-I ligand SLR14

| PRJNA421899 | ENA

Differential RNASeq of human bronchial and nasal epithelial cells stimulated with RIG-I ligand SLR14

Project description:Differential RNASeq of human bronchial and nasal epithelial cells stimulated with RIG-I ligand SLR14

| PRJNA483482 | ENA

Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

Project description:Differential RNASeq of human bronchial epithelial cells stimulated with RIG-I ligand SLR14

| PRJNA421897 | ENA

Differential RNASeq of human bronchial and nasal epithelial cells stimulated with RIG-I ligand SLR14

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-07-30 | GSE117884 | GEO

Gene expression changes upon activation of RIG-I by a minimal potent RIG-I ligand

Project description:Gene expression changes upon activation of RIG-I by a minimal potent RIG-I ligand

| PRJNA418284 | ENA

RNA-seq comparison of gene induction in RIG-I stimulated old and young human monocytes

Project description:Goal: The goal of this study was to compare gene induction in old and young human monocytes upon stimulation of these cells with a RIG-I specific ligand, based on previously published results which indicated impaired interferon responses in monocytes from older individuals upon influenza virus infeciton.

2017-12-31 | GSE100709 | GEO

Gene expression changes upon activation of RIG-I by a minimal potent RIG-I ligand

Project description:We have developed highly potent synthetic activators of the vertebrate immune system that specifically target the RIG-I receptor. When introduced into mice, a family of short, triphosphorylated Stem Loop RNAs (SLRs) induces a potent interferon response and the activation of specific genes essential for antiviral defense. Using RNAseq, we provide the first in-vivo genome-wide view of the expression networks that are initiated upon RIG-I activation. We observe that SLRs specifically induce type I interferons, subsets of interferon-stimulated genes (ISGs), and cellular remodeling factors. By contrast, poly(I:C), which binds and activates multiple RNA sensors, induces type III interferons and several unique ISGs. The short length (10-14 base pairs) and robust function of SLRs in mice demonstrate that RIG-I forms active signaling complexes without oligomerizing on RNA. These findings demonstrate that SLRs are potent therapeutic and investigative tools for targeted modulation of the innate immune system.

2018-02-03 | GSE106229 | GEO

Identification of avian RIG-I responsive genes during influenza infection

Project description:Transcriptional profiling of chicken embryonic fibroblasts (DF-1 cells) comparing the effects of chicken cells transfected with duck RIG-I compared to empty-vector transfected cells following with low or highly pathogenic avian influenza. Goal was to determine the effects of duck RIG-I on influenza-induced immune gene expression. Two-condition experiment. Biological replicates for low pathogenic avian influenza infection: 3 empty-vector transfected replicates, 3 RIG-I transfected replicates. Biological replicates for highly pathogenic influenza infection: 2 empty-vector transfected replicates, 2 RIG-I transfected replicates.

2012-12-12 | E-GEOD-29596 | biostudies-arrayexpress

Synthetic RIG-I agonist-mediated cancer immunotherapy synergizes with MAP-Kinase inhibition against BRAF mutated melanoma

Project description:The implementations of targeted molecular therapies and immunotherapy in melanoma vastly improved the therapeutic outcome in patients with limited efficacy of surgical intervention. Nevertheless, a large fraction of melanoma patients still remains refractory or acquires resistance to these new forms of treatment, illustrating a need for improvement. Here we report that the clinically relevant combination of MAP kinase inhibitors Dabrafenib and Trametinib synergizes with RIG-I agonist-induced immunotherapy to kill BRAF-mutated human and mouse melanoma cells. Kinase inhibition did not compromise the agonist-induced innate immune response of the RIG-I pathway in host immune cells. In a melanoma transplantation mouse model, the triple therapy outperformed the individual therapies. Our study suggests that targeted activation of RIG-I with its synthetic ligand 3pRNA could vastly improve tumor control in a substantial fraction of melanoma patients receiving MAP kinase inhibitors.

2024-07-26 | GSE268982 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data